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Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U. Oppelt A, et al. Among authors: zhang f. NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29900006 Free PMC article.
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.
Baxter M, Withey S, Harrison S, Segeritz CP, Zhang F, Atkinson-Dell R, Rowe C, Gerrard DT, Sison-Young R, Jenkins R, Henry J, Berry AA, Mohamet L, Best M, Fenwick SW, Malik H, Kitteringham NR, Goldring CE, Piper Hanley K, Vallier L, Hanley NA. Baxter M, et al. Among authors: zhang f. J Hepatol. 2015 Mar;62(3):581-9. doi: 10.1016/j.jhep.2014.10.016. Epub 2014 Oct 18. J Hepatol. 2015. PMID: 25457200 Free PMC article.
MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.
Kia R, Kelly L, Sison-Young RL, Zhang F, Pridgeon CS, Heslop JA, Metcalfe P, Kitteringham NR, Baxter M, Harrison S, Hanley NA, Burke ZD, Storm MP, Welham MJ, Tosh D, Küppers-Munther B, Edsbagge J, Starkey Lewis PJ, Bonner F, Harpur E, Sidaway J, Bowes J, Fenwick SW, Malik H, Goldring CE, Park BK. Kia R, et al. Among authors: zhang f. Toxicol Sci. 2015 Mar;144(1):173-85. doi: 10.1093/toxsci/kfu269. Epub 2014 Dec 18. Toxicol Sci. 2015. PMID: 25527335 Free PMC article.
Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK. Goldring C, et al. Among authors: zhang f. Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30. Hepatology. 2017. PMID: 27775817 Free PMC article. Review.
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
Chan BKY, Elmasry M, Forootan SS, Russomanno G, Bunday TM, Zhang F, Brillant N, Starkey Lewis PJ, Aird R, Ricci E, Andrews TD, Sison-Young RL, Schofield AL, Fang Y, Lister A, Sharkey JW, Poptani H, Kitteringham NR, Forbes SJ, Malik HZ, Fenwick SW, Park BK, Goldring CE, Copple IM. Chan BKY, et al. Among authors: zhang f. Hepatology. 2021 Aug;74(2):973-986. doi: 10.1002/hep.31859. Epub 2021 Jul 13. Hepatology. 2021. PMID: 33872408
In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells.
Pridgeon CS, Forootan SS, Zhang F, Harper N, Palmer D, Weightmann R, Gregory S, Hewitt Z, Baker D, Halliwell J, Moore H, Ricci E, Andrews PW, Poptani H, Hay DC, Park BK, Goldring CEP. Pridgeon CS, et al. Among authors: zhang f. J Stem Cells Regen Med. 2023 Apr 30;19(1):3-13. doi: 10.46582/jsrm.1901002. eCollection 2023. J Stem Cells Regen Med. 2023. PMID: 37366409 Free PMC article.
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