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Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U. Oppelt A, et al. Among authors: van de water b. NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29900006 Free PMC article.
Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death.
van der Sluis TC, van Duikeren S, Huppelschoten S, Jordanova ES, Beyranvand Nejad E, Sloots A, Boon L, Smit VT, Welters MJ, Ossendorp F, van de Water B, Arens R, van der Burg SH, Melief CJ. van der Sluis TC, et al. Among authors: van duikeren s, van de water b, van der burg sh. Clin Cancer Res. 2015 Feb 15;21(4):781-94. doi: 10.1158/1078-0432.CCR-14-2142. Epub 2014 Dec 12. Clin Cancer Res. 2015. PMID: 25501579
Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK. Goldring C, et al. Among authors: van de water b. Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30. Hepatology. 2017. PMID: 27775817 Free PMC article. Review.
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.
Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, Rainbow L, Fang Y, Sutherland JJ, Ellis EC, Ingelman-Sundberg M, Fenwick SW, Goldring CE, van de Water B, Stevens JL, Park BK. Copple IM, et al. Among authors: van de water b. Arch Toxicol. 2019 Feb;93(2):385-399. doi: 10.1007/s00204-018-2354-1. Epub 2018 Nov 13. Arch Toxicol. 2019. PMID: 30426165 Free PMC article.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: van de water b. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.
The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro.
Giustarini G, Huppelschoten S, Barra M, Oppelt A, Wagenaar L, Weaver RJ, Bol-Schoenmakers M, Smit JJ, van de Water B, Klingmüller U, Pieters RHH. Giustarini G, et al. Among authors: van de water b. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6. Toxicol Appl Pharmacol. 2020. PMID: 32035082
Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study.
Mav D, Phadke DP, Balik-Meisner MR, Merrick BA, Auerbach S, Niemeijer M, Huppelschoten S, Baze A, Parmentier C, Richert L, van de Water B, Shah RR, Paules RS. Mav D, et al. Among authors: van de water b. Bioinform Biol Insights. 2020 Sep 29;14:1177932220952742. doi: 10.1177/1177932220952742. eCollection 2020. Bioinform Biol Insights. 2020. PMID: 33088175 Free PMC article.
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes.
Ter Braak B, Niemeijer M, Boon R, Parmentier C, Baze A, Richert L, Huppelschoten S, Wink S, Verfaillie C, van de Water B. Ter Braak B, et al. Among authors: van de water b. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3. Toxicol In Vitro. 2021. PMID: 33545341 Free article.
Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure.
Hiemstra S, Fehling-Kaschek M, Kuijper IA, Bischoff LJM, Wijaya LS, Rosenblatt M, Esselink J, van Egmond A, Mos J, Beltman JB, Timmer J, van de Water B, Kaschek D. Hiemstra S, et al. Among authors: van egmond a, van de water b. Sci Rep. 2022 May 5;12(1):7336. doi: 10.1038/s41598-022-10857-x. Sci Rep. 2022. PMID: 35513409 Free PMC article.
251 results