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Conformational biosensors reveal GPCR signalling from endosomes.
Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Irannejad R, et al. Among authors: sunahara rk. Nature. 2013 Mar 28;495(7442):534-8. doi: 10.1038/nature12000. Epub 2013 Mar 20. Nature. 2013. PMID: 23515162 Free PMC article.
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.
DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. DeVree BT, et al. Among authors: sunahara rk. Nature. 2016 Jul 7;535(7610):182-6. doi: 10.1038/nature18324. Epub 2016 Jun 29. Nature. 2016. PMID: 27362234 Free PMC article.
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ. Thomsen ARB, et al. Among authors: sunahara rk. Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4. Cell. 2016. PMID: 27499021 Free PMC article.
Mechanistic insights into GPCR-G protein interactions.
Mahoney JP, Sunahara RK. Mahoney JP, et al. Among authors: sunahara rk. Curr Opin Struct Biol. 2016 Dec;41:247-254. doi: 10.1016/j.sbi.2016.11.005. Epub 2016 Nov 18. Curr Opin Struct Biol. 2016. PMID: 27871057 Free PMC article. Review.
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.
Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK. Masureel M, et al. Among authors: sunahara rk. Nat Chem Biol. 2018 Nov;14(11):1059-1066. doi: 10.1038/s41589-018-0145-x. Epub 2018 Oct 16. Nat Chem Biol. 2018. PMID: 30327561 Free PMC article.
129 results