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Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo.
Lv P, Miao SB, Shu YN, Dong LH, Liu G, Xie XL, Gao M, Wang YC, Yin YJ, Wang XJ, Han M. Lv P, et al. Among authors: han m. Circ Res. 2012 Aug 31;111(6):697-707. doi: 10.1161/CIRCRESAHA.112.272013. Epub 2012 Jul 12. Circ Res. 2012. PMID: 22798525
Accumulation of Smooth Muscle 22α Protein Accelerates Senescence of Vascular Smooth Muscle Cells via Stabilization of p53 In Vitro and In Vivo.
Miao SB, Xie XL, Yin YJ, Zhao LL, Zhang F, Shu YN, Chen R, Chen P, Dong LH, Lin YL, Lv P, Zhang DD, Nie X, Xue ZY, Han M. Miao SB, et al. Among authors: han m. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1849-1859. doi: 10.1161/ATVBAHA.117.309378. Epub 2017 Aug 10. Arterioscler Thromb Vasc Biol. 2017. PMID: 28798142
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