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Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.
Jones MG, Andriotis OG, Roberts JJ, Lunn K, Tear VJ, Cao L, Ask K, Smart DE, Bonfanti A, Johnson P, Alzetani A, Conforti F, Doherty R, Lai CY, Johnson B, Bourdakos KN, Fletcher SV, Marshall BG, Jogai S, Brereton CJ, Chee SJ, Ottensmeier CH, Sime P, Gauldie J, Kolb M, Mahajan S, Fabre A, Bhaskar A, Jarolimek W, Richeldi L, O'Reilly KM, Monk PD, Thurner PJ, Davies DE. Jones MG, et al. Among authors: conforti f. Elife. 2018 Jul 3;7:e36354. doi: 10.7554/eLife.36354. Elife. 2018. PMID: 29966587 Free PMC article.
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis.
Brereton CJ, Yao L, Davies ER, Zhou Y, Vukmirovic M, Bell JA, Wang S, Ridley RA, Dean LSN, Andriotis OG, Conforti F, Brewitz L, Mohammed S, Wallis T, Tavassoli A, Ewing RM, Alzetani A, Marshall BG, Fletcher SV, Thurner PJ, Fabre A, Kaminski N, Richeldi L, Bhaskar A, Schofield CJ, Loxham M, Davies DE, Wang Y, Jones MG. Brereton CJ, et al. Among authors: conforti f. Elife. 2022 Feb 21;11:e69348. doi: 10.7554/eLife.69348. Elife. 2022. PMID: 35188460 Free PMC article.
The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.
Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, Ganesan A, Skipp PJ, Marshall BJ, Richeldi L, Sime PJ, O'Reilly KMA, Davies DE. Conforti F, et al. Oncotarget. 2017 Jul 25;8(30):48737-48754. doi: 10.18632/oncotarget.17114. Oncotarget. 2017. PMID: 28467787 Free PMC article.
Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.
Yao L, Conforti F, Hill C, Bell J, Drawater L, Li J, Liu D, Xiong H, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Coldwell M, Yuan X, Ottensmeier CH, Downward J, Collins JE, Ewing RM, Richeldi L, Skipp P, Jones MG, Davies DE, Wang Y. Yao L, et al. Among authors: conforti f. Cell Death Differ. 2019 May;26(5):943-957. doi: 10.1038/s41418-018-0175-7. Epub 2018 Jul 26. Cell Death Differ. 2019. PMID: 30050057 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33563935
Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis.
Hill C, Li J, Liu D, Conforti F, Brereton CJ, Yao L, Zhou Y, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Ottensmeier CH, Steele AJ, Downward J, Richeldi L, Lu X, Davies DE, Jones MG, Wang Y. Hill C, et al. Among authors: conforti f. Cell Death Dis. 2019 Aug 7;10(8):591. doi: 10.1038/s41419-019-1820-x. Cell Death Dis. 2019. PMID: 31391462 Free PMC article.
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis.
Yao L, Zhou Y, Li J, Wickens L, Conforti F, Rattu A, Ibrahim FM, Alzetani A, Marshall BG, Fletcher SV, Hancock D, Wallis T, Downward J, Ewing RM, Richeldi L, Skipp P, Davies DE, Jones MG, Wang Y. Yao L, et al. Among authors: conforti f. J Biol Chem. 2021 Sep;297(3):101096. doi: 10.1016/j.jbc.2021.101096. Epub 2021 Aug 18. J Biol Chem. 2021. PMID: 34418430 Free PMC article.
402 results