Dai XQ - Search Results

1

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL. Thomsen SK, et al. Among authors: dai xq. Nat Genet. 2018 Aug;50(8):1122-1131. doi: 10.1038/s41588-018-0173-1. Epub 2018 Jul 27. Nat Genet. 2018. PMID: 30054598 Free PMC article.

2

SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability.

Dai XQ, Kolic J, Marchi P, Sipione S, Macdonald PE. Dai XQ, et al. J Cell Sci. 2009 Mar 15;122(Pt 6):775-9. doi: 10.1242/jcs.036632. Epub 2009 Feb 17. J Cell Sci. 2009. PMID: 19223394

3

Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

Hamming KS, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JR, Macdonald PE, Light PE. Hamming KS, et al. Among authors: dai xq. Diabetes. 2010 Jul;59(7):1686-93. doi: 10.2337/db09-0630. Epub 2010 Apr 22. Diabetes. 2010. PMID: 20413506 Free PMC article.

4

Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans.

Spigelman AF, Dai X, MacDonald PE. Spigelman AF, et al. Diabetologia. 2010 Sep;53(9):1917-26. doi: 10.1007/s00125-010-1759-z. Epub 2010 May 6. Diabetologia. 2010. PMID: 20446079

5

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.

Dai XQ, Plummer G, Casimir M, Kang Y, Hajmrle C, Gaisano HY, Manning Fox JE, MacDonald PE. Dai XQ, et al. Diabetes. 2011 Mar;60(3):838-47. doi: 10.2337/db10-0440. Epub 2011 Jan 24. Diabetes. 2011. PMID: 21266332 Free PMC article.

6

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.

Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, Hayden MR. Kruit JK, et al. Among authors: dai xq. Diabetes. 2011 Dec;60(12):3186-96. doi: 10.2337/db11-0081. Epub 2011 Oct 12. Diabetes. 2011. PMID: 21998401 Free PMC article.

7

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE. Dai XQ, et al. Diabetologia. 2012 Jun;55(6):1709-20. doi: 10.1007/s00125-012-2512-6. Epub 2012 Mar 13. Diabetologia. 2012. PMID: 22411134

8

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.

Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M. Cai EP, et al. Among authors: dai xq. Diabetes. 2012 Jul;61(7):1708-18. doi: 10.2337/db11-1344. Epub 2012 Apr 12. Diabetes. 2012. PMID: 22498697 Free PMC article.

9

Functional plasticity of the human infant β-cell exocytotic phenotype.

Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE. Fox JE, et al. Among authors: dai xq. Endocrinology. 2013 Apr;154(4):1392-9. doi: 10.1210/en.2012-1934. Epub 2013 Feb 28. Endocrinology. 2013. PMID: 23449893

10

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells.

Dai XQ, Spigelman AF, Khan S, Braun M, Manning Fox JE, MacDonald PE. Dai XQ, et al. J Physiol. 2014 Sep 1;592(17):3715-26. doi: 10.1113/jphysiol.2014.274084. Epub 2014 Jun 6. J Physiol. 2014. PMID: 24907310 Free PMC article.

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