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Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.
Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF. Tricoci P, et al. Among authors: edelstein lc. Blood Cells Mol Dis. 2018 Sep;72:37-43. doi: 10.1016/j.bcmd.2018.07.004. Epub 2018 Jul 21. Blood Cells Mol Dis. 2018. PMID: 30055940 Free PMC article. Clinical Trial.
The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.
Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF. Whitley MJ, et al. Among authors: edelstein lc. J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22. J Thromb Haemost. 2018. PMID: 30347494 Free PMC article.
MicroRNAs in platelet production and activation.
Edelstein LC, Bray PF. Edelstein LC, et al. Blood. 2011 May 19;117(20):5289-96. doi: 10.1182/blood-2011-01-292011. Epub 2011 Mar 1. Blood. 2011. PMID: 21364189 Free PMC article. Review.
Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Tourdot BE, et al. Among authors: edelstein lc. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1632-1643. doi: 10.1161/ATVBAHA.118.311112. Epub 2018 May 10. Arterioscler Thromb Vasc Biol. 2018. PMID: 29748334 Free PMC article.
42 results