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A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes.
Roy Chowdhury R, Vallania F, Yang Q, Lopez Angel CJ, Darboe F, Penn-Nicholson A, Rozot V, Nemes E, Malherbe ST, Ronacher K, Walzl G, Hanekom W, Davis MM, Winter J, Chen X, Scriba TJ, Khatri P, Chien YH. Roy Chowdhury R, et al. Among authors: darboe f. Nature. 2018 Aug;560(7720):644-648. doi: 10.1038/s41586-018-0439-x. Epub 2018 Aug 22. Nature. 2018. PMID: 30135583 Free PMC article.
Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes.
Roy Chowdhury R, Vallania F, Yang Q, Lopez Angel CJ, Darboe F, Penn-Nicholson A, Rozot V, Nemes E, Malherbe ST, Ronacher K, Walzl G, Hanekom W, Davis MM, Winter J, Chen X, Scriba TJ, Khatri P, Chien YH. Roy Chowdhury R, et al. Among authors: darboe f. Nature. 2018 Dec;564(7734):E5. doi: 10.1038/s41586-018-0635-8. Nature. 2018. PMID: 30377311 Free PMC article.
T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher HA, Snowden MA, Landry B, Rida W, Satti I, Harris SA, Matsumiya M, Tanner R, O'Shea MK, Dheenadhayalan V, Bogardus L, Stockdale L, Marsay L, Chomka A, Harrington-Kandt R, Manjaly-Thomas ZR, Naranbhai V, Stylianou E, Darboe F, Penn-Nicholson A, Nemes E, Hatherill M, Hussey G, Mahomed H, Tameris M, McClain JB, Evans TG, Hanekom WA, Scriba TJ, McShane H. Fletcher HA, et al. Among authors: darboe f. Nat Commun. 2016 Apr 12;7:11290. doi: 10.1038/ncomms11290. Nat Commun. 2016. PMID: 27068708 Free PMC article. Clinical Trial.
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.
Scriba TJ, Penn-Nicholson A, Shankar S, Hraha T, Thompson EG, Sterling D, Nemes E, Darboe F, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Johnson JL, Boom WH, Hatherill M, Valvo J, De Groote MA, Ochsner UA, Aderem A, Hanekom WA, Zak DE; other members of the ACS cohort study team. Scriba TJ, et al. Among authors: darboe f. PLoS Pathog. 2017 Nov 16;13(11):e1006687. doi: 10.1371/journal.ppat.1006687. eCollection 2017 Nov. PLoS Pathog. 2017. PMID: 29145483 Free PMC article. Clinical Trial.
Plasma Type I IFN Protein Concentrations in Human Tuberculosis.
Llibre A, Bilek N, Bondet V, Darboe F, Mbandi SK, Penn-Nicholson A, Hatherill M, Rozenberg F, Scriba TJ, Duffy D. Llibre A, et al. Among authors: darboe f. Front Cell Infect Microbiol. 2019 Aug 22;9:296. doi: 10.3389/fcimb.2019.00296. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31508378 Free PMC article.
Inflammatory Determinants of Differential Tuberculosis Risk in Pre-Adolescent Children and Young Adults.
Baguma R, Mbandi SK, Rodo MJ, Erasmus M, Day J, Makhethe L, de Kock M, van Rooyen M, Stone L, Bilek N, Steyn M, Africa H, Darboe F, Chegou NN, Tromp G, Walzl G, Hatherill M, Penn-Nicholson A, Scriba TJ. Baguma R, et al. Among authors: darboe f. Front Immunol. 2021 Feb 25;12:639965. doi: 10.3389/fimmu.2021.639965. eCollection 2021. Front Immunol. 2021. PMID: 33717192 Free PMC article.
Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.
Amelio P, Portevin D, Reither K, Mhimbira F, Mpina M, Tumbo A, Nickel B, Marti H, Knopp S, Ding S, Penn-Nicholson A, Darboe F, Ohmiti K, Scriba TJ, Pantaleo G, Daubenberger C, Perreau M. Amelio P, et al. Among authors: darboe f. PLoS Negl Trop Dis. 2017 Jul 31;11(7):e0005817. doi: 10.1371/journal.pntd.0005817. eCollection 2017 Jul. PLoS Negl Trop Dis. 2017. PMID: 28759590 Free PMC article.
Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.
Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Maasdorp DB, Van Reenen M, Zak DE, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F. Parihar SP, et al. Among authors: darboe f. Mucosal Immunol. 2018 Mar;11(2):496-511. doi: 10.1038/mi.2017.68. Epub 2017 Aug 9. Mucosal Immunol. 2018. PMID: 28832027 Free article.
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response.
Penn-Nicholson A, Mbandi SK, Thompson E, Mendelsohn SC, Suliman S, Chegou NN, Malherbe ST, Darboe F, Erasmus M, Hanekom WA, Bilek N, Fisher M, Kaufmann SHE, Winter J, Murphy M, Wood R, Morrow C, Van Rhijn I, Moody B, Murray M, Andrade BB, Sterling TR, Sutherland J, Naidoo K, Padayatchi N, Walzl G, Hatherill M, Zak D, Scriba TJ; Adolescent Cohort Study team; GC6-74 Consortium; SATVI Clinical and Laboratory Team; ScreenTB Consortium; AE-TBC Consortium; RePORT Brazil Team; Peruvian Household Contacts Cohort Team; CAPRISA IMPRESS team. Penn-Nicholson A, et al. Among authors: darboe f. Sci Rep. 2020 May 25;10(1):8629. doi: 10.1038/s41598-020-65043-8. Sci Rep. 2020. PMID: 32451443 Free PMC article.
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