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Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.
Ndungu JM, Krumm SA, Yan D, Arrendale RF, Reddy GP, Evers T, Howard R, Natchus MG, Saindane MT, Liotta DC, Plemper RK, Snyder JP, Sun A. Ndungu JM, et al. Among authors: natchus mg. J Med Chem. 2012 May 10;55(9):4220-30. doi: 10.1021/jm201699w. Epub 2012 Apr 20. J Med Chem. 2012. PMID: 22480182 Free PMC article.
Asymmetric synthesis of host-directed inhibitors of myxoviruses.
Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A. Moore TW, et al. Among authors: natchus mg. Beilstein J Org Chem. 2013;9:197-203. doi: 10.3762/bjoc.9.23. Epub 2013 Jan 30. Beilstein J Org Chem. 2013. PMID: 23400228 Free PMC article.
Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy.
Moore TW, Sana K, Yan D, Krumm SA, Thepchatri P, Snyder JP, Marengo J, Arrendale RF, Prussia AJ, Natchus MG, Liotta DC, Plemper RK, Sun A. Moore TW, et al. Among authors: natchus mg. ACS Med Chem Lett. 2013 Aug 8;4(8):762-767. doi: 10.1021/ml400166b. ACS Med Chem Lett. 2013. PMID: 23956816 Free PMC article.
An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.
Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK. Krumm SA, et al. Among authors: natchus mg. Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517. Sci Transl Med. 2014. PMID: 24739760 Free PMC article.
Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer.
Garnier-Amblard EC, Mays SG, Arrendale RF, Baillie MT, Bushnev AS, Culver DG, Evers TJ, Holt JJ, Howard RB, Liebeskind LS, Menaldino DS, Natchus MG, Petros JA, Ramaraju H, Reddy GP, Liotta DC. Garnier-Amblard EC, et al. Among authors: natchus mg. ACS Med Chem Lett. 2011 Mar 25;2(6):438-43. doi: 10.1021/ml2000164. eCollection 2011 Jun 9. ACS Med Chem Lett. 2011. PMID: 24900327 Free PMC article.
Sphingolipid analogues inhibit development of malaria parasites.
Meyer EV, Holt JJ, Girard KR, Ballie MT, Bushnev AS, Lapp S, Menaldino DS, Arrendale RF, Reddy GP, Evers TJ, Howard RB, Culver DG, Liotta DC, Galinski MR, Natchus MG. Meyer EV, et al. Among authors: natchus mg. ACS Med Chem Lett. 2011 Dec 6;3(1):43-7. doi: 10.1021/ml2002136. eCollection 2012 Jan 12. ACS Med Chem Lett. 2011. PMID: 24900369 Free PMC article.
Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury.
Guthrie DB, Stein DG, Liotta DC, Lockwood MA, Sayeed I, Atif F, Arrendale RF, Reddy GP, Evers TJ, Marengo JR, Howard RB, Culver DG, Natchus MG. Guthrie DB, et al. Among authors: natchus mg. ACS Med Chem Lett. 2012 Mar 15;3(5):362-6. doi: 10.1021/ml200303r. eCollection 2012 May 10. ACS Med Chem Lett. 2012. PMID: 24900479 Free PMC article.
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.
Truax VM, Zhao H, Katzman BM, Prosser AR, Alcaraz AA, Saindane MT, Howard RB, Culver D, Arrendale RF, Gruddanti PR, Evers TJ, Natchus MG, Snyder JP, Liotta DC, Wilson LJ. Truax VM, et al. Among authors: natchus mg. ACS Med Chem Lett. 2013 Sep 5;4(11):1025-30. doi: 10.1021/ml400183q. eCollection 2013 Nov 14. ACS Med Chem Lett. 2013. PMID: 24936240 Free PMC article.
Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.
Miller EJ, Mays SG, Baillie MT, Howard RB, Culver DG, Saindane M, Pruett ST, Holt JJ, Menaldino DS, Evers TJ, Reddy GP, Arrendale RF, Natchus MG, Petros JA, Liotta DC. Miller EJ, et al. Among authors: natchus mg. ACS Med Chem Lett. 2016 Mar 21;7(5):537-42. doi: 10.1021/acsmedchemlett.6b00113. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190606 Free PMC article.
61 results