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One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Diedrich D, Stenzel K, Hesping E, Antonova-Koch Y, Gebru T, Duffy S, Fisher G, Schöler A, Meister S, Kurz T, Avery VM, Winzeler EA, Held J, Andrews KT, Hansen FK. Diedrich D, et al. Among authors: hansen fk. Eur J Med Chem. 2018 Oct 5;158:801-813. doi: 10.1016/j.ejmech.2018.09.018. Epub 2018 Sep 7. Eur J Med Chem. 2018. PMID: 30245402 Free PMC article.
Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.
Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT. Trenholme K, et al. Among authors: hansen fk. Antimicrob Agents Chemother. 2014 Jul;58(7):3666-78. doi: 10.1128/AAC.02721-13. Epub 2014 Apr 14. Antimicrob Agents Chemother. 2014. PMID: 24733477 Free PMC article.
HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells.
Xiao H, Jiao J, Wang L, O'Brien S, Newick K, Wang LC, Falkensammer E, Liu Y, Han R, Kapoor V, Hansen FK, Kurz T, Hancock WW, Beier UH. Xiao H, et al. Among authors: hansen fk. Int J Cancer. 2016 May 15;138(10):2477-86. doi: 10.1002/ijc.29979. Epub 2016 Jan 19. Int J Cancer. 2016. PMID: 26704363 Free PMC article.
99 results