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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells.
Ward NC, Yu A, Moro A, Ban Y, Chen X, Hsiung S, Keegan J, Arbanas JM, Loubeau M, Thankappan A, Yamniuk AP, Davis JH, Struthers M, Malek TR. Ward NC, et al. Among authors: struthers m. J Immunol. 2018 Nov 1;201(9):2579-2592. doi: 10.4049/jimmunol.1800907. Epub 2018 Oct 3. J Immunol. 2018. PMID: 30282751 Free PMC article.
Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus.
Xie JH, Zhang Y, Loubeau M, Mangan P, Heimrich E, Tovar C, Zhou X, Madia P, Doyle M, Dudhgaonkar S, Rudra A, Subramani S, Young J, Salter-Cid L, Malek TR, Struthers M. Xie JH, et al. Among authors: struthers m. J Immunol. 2021 Jul 1;207(1):34-43. doi: 10.4049/jimmunol.2100078. Epub 2021 Jun 9. J Immunol. 2021. PMID: 34108258
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
Mangan PR, Su LJ, Jenny V, Tatum AL, Picarillo C, Skala S, Ditto N, Lin Z, Yang X, Cotter PZ, Shuster DJ, Song Y, Borowski V, Thomas RL, Heimrich EM, Devaux B, Das Gupta R, Carvajal I, McIntyre KW, Xie J, Zhao Q, Struthers M, Salter-Cid LM. Mangan PR, et al. Among authors: struthers m. J Pharmacol Exp Ther. 2015 Aug;354(2):152-65. doi: 10.1124/jpet.115.224246. Epub 2015 May 26. J Pharmacol Exp Ther. 2015. PMID: 26015463
Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Struthers M, Bett AJ, Wisniewski T, Dubey SA, Precopio M, Jiang W, Sun Z, Wang H, Nowak I, Putta MR, Yu D, Tang JX, Kandimalla ER, Agrawal S, Casimiro DR. Struthers M, et al. Cell Immunol. 2010;263(1):105-13. doi: 10.1016/j.cellimm.2010.03.005. Epub 2010 Mar 10. Cell Immunol. 2010. PMID: 20381019
A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines.
Zhao Q, Kim T, Pang J, Sun W, Yang X, Wang J, Song Y, Zhang H, Sun H, Rangan V, Deshpande S, Tang H, Cvijic ME, Westhouse R, Olah T, Xie J, Struthers M, Salter-Cid L. Zhao Q, et al. Among authors: struthers m. J Leukoc Biol. 2017 Nov;102(5):1271-1280. doi: 10.1189/jlb.5A0717-302. Epub 2017 Sep 12. J Leukoc Biol. 2017. PMID: 28899907
Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.
Wisniewski T, Bayne E, Flanagan J, Shao Q, Wnek R, Matheravidathu S, Fischer P, Forrest MJ, Peterson L, Song X, Yang L, Demartino JA, Struthers M. Wisniewski T, et al. Among authors: struthers m. J Immunol Methods. 2010 Jan 31;352(1-2):101-10. doi: 10.1016/j.jim.2009.10.010. Epub 2009 Nov 10. J Immunol Methods. 2010. PMID: 19913021
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists.
Pinkerton AB, Huang D, Cube RV, Hutchinson JH, Struthers M, Ayala JM, Vicario PP, Patel SR, Wisniewski T, DeMartino JA, Vernier JM. Pinkerton AB, et al. Among authors: struthers m. Bioorg Med Chem Lett. 2007 Feb 1;17(3):807-13. doi: 10.1016/j.bmcl.2006.10.060. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17088058
65 results