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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors.
Yen I, Shanahan F, Merchant M, Orr C, Hunsaker T, Durk M, La H, Zhang X, Martin SE, Lin E, Chan J, Yu Y, Amin D, Neve RM, Gustafson A, Venkatanarayan A, Foster SA, Rudolph J, Klijn C, Malek S. Yen I, et al. Among authors: chan j. Cancer Cell. 2018 Oct 8;34(4):611-625.e7. doi: 10.1016/j.ccell.2018.09.002. Cancer Cell. 2018. PMID: 30300582 Free article.
Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.
Smith A, Ni ZJ, Poon D, Huang Z, Chen Z, Zhang Q, Tandeske L, Merritt H, Shoemaker K, Chan J, Kaufman S, Huh K, Murray J, Appleton BA, Cowan-Jacob SW, Scheufler C, Kanazawa T, Jansen JM, Stuart D, Shafer CM. Smith A, et al. Among authors: chan j. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5221-5224. doi: 10.1016/j.bmcl.2017.10.047. Epub 2017 Oct 20. Bioorg Med Chem Lett. 2017. PMID: 29107542
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Pecchi S, Ni ZJ, Han W, Smith A, Lan J, Burger M, Merritt H, Wiesmann M, Chan J, Kaufman S, Knapp MS, Janssen J, Huh K, Voliva CF. Pecchi S, et al. Among authors: chan j. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4652-6. doi: 10.1016/j.bmcl.2013.06.010. Epub 2013 Jun 12. Bioorg Med Chem Lett. 2013. PMID: 23820386
Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors.
Sato K, Hoe LS, Chan J, Obonyo NG, Wildi K, Heinsar S, Colombo SM, Ainola C, Abbate G, Sato N, Passmore MR, Bouquet M, Wilson ES, Hyslop K, Livingstone S, Haymet A, Jung JS, Skeggs K, Palmieri C, White N, Platts D, Suen JY, McGiffin DC, Bassi GL, Fraser JF. Sato K, et al. Among authors: chan j. Eur J Clin Invest. 2024 Jun 6:e14259. doi: 10.1111/eci.14259. Online ahead of print. Eur J Clin Invest. 2024. PMID: 38845111
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer.
Yin J, Chen J, Hong JH, Huang Y, Xiao R, Liu S, Deng P, Sun Y, Chai KXY, Zeng X, Chan JY, Guan P, Wang Y, Wang P, Tong C, Yu Q, Xia X, Ong CK, Teh BT, Xiong Y, Tan J. Yin J, et al. Among authors: chan jy. JCI Insight. 2024 Jun 6:e177857. doi: 10.1172/jci.insight.177857. Online ahead of print. JCI Insight. 2024. PMID: 38842940 Free article.
Patient-reported outcomes and treatment adherence in type 2 diabetes using natural language processing: Wave 8 of the Observational International Diabetes Management Practices Study.
Chan JC, Mbanya JC, Chantelot JM, Shestakova M, Ramachandran A, Ilkova H, Deplante L, Rollot M, Melas-Melt L, Gagliardino JJ, Aschner P. Chan JC, et al. J Diabetes Investig. 2024 Jun 5. doi: 10.1111/jdi.14228. Online ahead of print. J Diabetes Investig. 2024. PMID: 38840439 Free article.
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