Segditsas S - Search Results

1

Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis.

Lee LYW, Woolley C, Starkey T, Biswas S, Mirshahi T, Bardella C, Segditsas S, Irshad S, Tomlinson I. Lee LYW, et al. Among authors: segditsas s. Clin Cancer Res. 2019 Jan 15;25(2):629-640. doi: 10.1158/1078-0432.CCR-18-1033. Epub 2018 Oct 15. Clin Cancer Res. 2019. PMID: 30322876 Free PMC article.

2

Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

Lessi F, Beggs A, de Palo M, Anti M, Macarone Palmieri R, Francesconi S, Gomes V, Bevilacqua G, Tomlinson I, Segditsas S. Lessi F, et al. Among authors: segditsas s. PLoS One. 2010 Nov 5;5(11):e13840. doi: 10.1371/journal.pone.0013840. PLoS One. 2010. PMID: 21079778 Free PMC article.

3

Colorectal cancer and genetic alterations in the Wnt pathway.

Segditsas S, Tomlinson I. Segditsas S, et al. Oncogene. 2006 Dec 4;25(57):7531-7. doi: 10.1038/sj.onc.1210059. Oncogene. 2006. PMID: 17143297 Review.

4

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. Sakthianandeswaren A, et al. Among authors: segditsas s. Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10. Cancer Res. 2011. PMID: 21558389 Free article.

5

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Lewis A, Segditsas S, Deheragoda M, Pollard P, Jeffery R, Nye E, Lockstone H, Davis H, Clark S, Stamp G, Poulsom R, Wright N, Tomlinson I. Lewis A, et al. Among authors: segditsas s. Gut. 2010 Dec;59(12):1680-6. doi: 10.1136/gut.2009.193680. Epub 2010 Oct 6. Gut. 2010. PMID: 20926645 Free PMC article.

6

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Segditsas S, Sieber OM, Rowan A, Setien F, Neale K, Phillips RK, Ward R, Esteller M, Tomlinson IP. Segditsas S, et al. Exp Mol Pathol. 2008 Dec;85(3):201-6. doi: 10.1016/j.yexmp.2008.09.006. Epub 2008 Oct 11. Exp Mol Pathol. 2008. PMID: 18977219

7

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I. Pollard P, et al. Among authors: segditsas s. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25. Gastroenterology. 2009. PMID: 19248780

8

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.

Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, Segditsas S, Davis H, Jeffery R, Rodriguez-Justo M, Keshav S, Travis SP, Graham TA, East J, Clark S, Tomlinson IP. Leedham SJ, et al. Among authors: segditsas s. Gut. 2013 Jan;62(1):83-93. doi: 10.1136/gutjnl-2011-301601. Epub 2012 Jan 27. Gut. 2013. PMID: 22287596 Free PMC article.

9

The C-terminus of Apc does not influence intestinal adenoma development or progression.

Lewis A, Davis H, Deheragoda M, Pollard P, Nye E, Jeffery R, Segditsas S, East P, Poulsom R, Stamp G, Wright N, Tomlinson I. Lewis A, et al. Among authors: segditsas s. J Pathol. 2012 Jan;226(1):73-83. doi: 10.1002/path.2972. Epub 2011 Oct 18. J Pathol. 2012. PMID: 22009253 Free PMC article.

10

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.

Thirlwell C, Howarth KM, Segditsas S, Guerra G, Thomas HJ, Phillips RK, Talbot IC, Gorman M, Novelli MR, Sieber OM, Tomlinson IP. Thirlwell C, et al. Among authors: segditsas s. Br J Cancer. 2007 Jun 4;96(11):1729-34. doi: 10.1038/sj.bjc.6603789. Epub 2007 May 15. Br J Cancer. 2007. PMID: 17505512 Free PMC article.

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