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Phenome-wide association studies across large population cohorts support drug target validation.
Diogo D, Tian C, Franklin CS, Alanne-Kinnunen M, March M, Spencer CCA, Vangjeli C, Weale ME, Mattsson H, Kilpeläinen E, Sleiman PMA, Reilly DF, McElwee J, Maranville JC, Chatterjee AK, Bhandari A, Nguyen KH, Estrada K, Reeve MP, Hutz J, Bing N, John S, MacArthur DG, Salomaa V, Ripatti S, Hakonarson H, Daly MJ, Palotie A, Hinds DA, Donnelly P, Fox CS, Day-Williams AG, Plenge RM, Runz H. Diogo D, et al. Among authors: march m. Nat Commun. 2018 Oct 16;9(1):4285. doi: 10.1038/s41467-018-06540-3. Nat Commun. 2018. PMID: 30327483 Free PMC article.
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, Mortensen LJ, Paternoster L, Flaaten R, Mølgaard A, Smart DE, Thomsen PF, Rasmussen MA, Bonàs-Guarch S, Holst C, Nohr EA, Yadav R, March ME, Blicher T, Lackie PM, Jaddoe VW, Simpson A, Holloway JW, Duijts L, Custovic A, Davies DE, Torrents D, Gupta R, Hollegaard MV, Hougaard DM, Hakonarson H, Bisgaard H. Bønnelykke K, et al. Among authors: march me. Nat Genet. 2014 Jan;46(1):51-5. doi: 10.1038/ng.2830. Epub 2013 Nov 17. Nat Genet. 2014. PMID: 24241537
The genetic basis of eosinophilic esophagitis.
Sleiman PMA, March M, Hakonarson H. Sleiman PMA, et al. Among authors: march m. Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):701-707. doi: 10.1016/j.bpg.2015.09.003. Epub 2015 Sep 11. Best Pract Res Clin Gastroenterol. 2015. PMID: 26552769 Review.
Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene.
van Ingen G, Li J, Goedegebure A, Pandey R, Li YR, March ME, Jaddoe VW, Bakay M, Mentch FD, Thomas K, Wei Z, Chang X, Hain HS, Uitterlinden AG, Moll HA, van Duijn CM, Rivadeneira F, Raat H, Baatenburg de Jong RJ, Sleiman PM, van der Schroeff MP, Hakonarson H. van Ingen G, et al. Among authors: march me. Nat Commun. 2016 Sep 28;7:12792. doi: 10.1038/ncomms12792. Nat Commun. 2016. PMID: 27677580 Free PMC article.
Loss-of-Function Mutations in KIF15 Underlying a Braddock-Carey Genocopy.
Sleiman PMA, March M, Nguyen K, Tian L, Pellegrino R, Hou C, Dridi W, Sager M, Housawi YH, Hakonarson H. Sleiman PMA, et al. Among authors: march m. Hum Mutat. 2017 May;38(5):507-510. doi: 10.1002/humu.23188. Epub 2017 Mar 10. Hum Mutat. 2017. PMID: 28150392
Copy number variation meta-analysis reveals a novel duplication at 9p24 associated with multiple neurodevelopmental disorders.
Glessner JT, Li J, Wang D, March M, Lima L, Desai A, Hadley D, Kao C, Gur RE, Cohen N, Sleiman PMA, Li Q, Hakonarson H; Janssen-CHOP Neuropsychiatric Genomics Working Group. Glessner JT, et al. Among authors: march m. Genome Med. 2017 Nov 30;9(1):106. doi: 10.1186/s13073-017-0494-1. Genome Med. 2017. PMID: 29191242 Free PMC article.
180 results