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Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.
Oliva-Vilarnau N, Vorrink SU, Büttner FA, Heinrich T, Sensbach J, Koscielski I, Wienke D, Petersson C, Perrin D, Lauschke VM. Oliva-Vilarnau N, et al. Among authors: lauschke vm. Biochem Pharmacol. 2023 Sep;215:115755. doi: 10.1016/j.bcp.2023.115755. Epub 2023 Aug 20. Biochem Pharmacol. 2023. PMID: 37607620 Free article.
Two different isoforms of osteopontin modulate myelination and axonal integrity.
Nilsson G, Mottahedin A, Zelco A, Lauschke VM, Ek CJ, Song J, Ardalan M, Hua S, Zhang X, Mallard C, Hagberg H, Leavenworth JW, Wang X. Nilsson G, et al. Among authors: lauschke vm. FASEB Bioadv. 2023 Jun 17;5(8):336-353. doi: 10.1096/fba.2023-00030. eCollection 2023 Aug. FASEB Bioadv. 2023. PMID: 37554545 Free PMC article.
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment.
Turner J, Pound P, Owen C, Hutchinson I, Hop M, Chau DYS, Barrios Silva LV, Coleman M, Dubourg A, Harries LW, Hutter V, Kenna JG, Lauschke VM, Neuhaus W, Roper C, Watkins PB, Welch J, Alvarez LR, Taylor K. Turner J, et al. Among authors: lauschke vm. ALTEX. 2023;40(3):519-533. doi: 10.14573/altex.2212081. Epub 2023 Jan 18. ALTEX. 2023. PMID: 36692187 Free article.
Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
Khor CC, Winter S, Sutiman N, Mürdter TE, Chen S, Lim JSL, Li Z, Li J, Sim KS, Ganchev B, Eccles D, Eccles B, Tapper W, Zgheib NK, Tfayli A, Ng RCH, Yap YS, Lim E, Wong M, Wong NS, Ang PCS, Dent R, Tremmel R, Klein K, Schaeffeler E, Zhou Y, Lauschke VM, Eichelbaum M, Schwab M, Brauch HB, Chowbay B, Schroth W. Khor CC, et al. Among authors: lauschke vm. Clin Pharmacol Ther. 2023 Mar;113(3):712-723. doi: 10.1002/cpt.2846. Epub 2023 Jan 31. Clin Pharmacol Ther. 2023. PMID: 36629403
Genetic testing is superior over endogenous pharmacometabolomic markers to predict safety of haloperidol in patients with alcohol-induced psychotic disorder.
Skryabin V, Zastrozhin M, Parkhomenko A, Lauschke VM, Smirnov V, Petukhov A, Pankratenko E, Pozdnyakov S, Koporov S, Denisenko N, Akmalova K, Bryun E, Sychev D. Skryabin V, et al. Among authors: lauschke vm. Curr Drug Metab. 2022 Dec 28. doi: 10.2174/1389200224666221228112643. Online ahead of print. Curr Drug Metab. 2022. PMID: 36579390
173 results