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Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases.
J Control Release. 2018 Dec 10;291:80-89. doi: 10.1016/j.jconrel.2018.10.017. Epub 2018 Oct 17.
J Control Release. 2018.
PMID: 30342077
Sustained intrathecal therapeutic protein delivery using genetically transduced tissue implants in a freely moving rat model.
Aronson JP, Katnani HA, Pomerantseva I, Shapir N, Tse H, Miari R, Goltsman H, Mwizerwa O, Neville CM, Neil GA, Eskandar EN, Sundback CA.
Aronson JP, et al. Among authors: goltsman h.
Int J Pharm. 2017 Dec 20;534(1-2):42-49. doi: 10.1016/j.ijpharm.2017.10.002. Epub 2017 Oct 3.
Int J Pharm. 2017.
PMID: 28986320
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Biopump: Autologous skin-derived micro-organ genetically engineered to provide sustained continuous secretion of therapeutic proteins.
Mitrani E, Pearlman A, Stern B, Miari R, Goltsman H, Kunicher N, Panet A.
Mitrani E, et al. Among authors: goltsman h.
Dermatol Ther. 2011 Sep-Oct;24(5):489-97. doi: 10.1111/j.1529-8019.2012.01457.x.
Dermatol Ther. 2011.
PMID: 22353155
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Sustained secretion of anti-tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis.
Zafir-Lavie I, Miari R, Sherbo S, Krispel S, Tal O, Liran A, Shatil T, Badinter F, Goltsman H, Shapir N, Benhar I, Neil GA, Panet A.
Zafir-Lavie I, et al. Among authors: goltsman h.
J Gene Med. 2017 Aug;19(8). doi: 10.1002/jgm.2965.
J Gene Med. 2017.
PMID: 28658716
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