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A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation.
Nat Cell Biol. 2018 Dec;20(12):1410-1420. doi: 10.1038/s41556-018-0221-1. Epub 2018 Nov 5.
Nat Cell Biol. 2018.
PMID: 30397315
Free PMC article.
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.
Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C.
Nakayama RT, et al. Among authors: cassel sh.
Nat Genet. 2017 Nov;49(11):1613-1623. doi: 10.1038/ng.3958. Epub 2017 Sep 25.
Nat Genet. 2017.
PMID: 28945250
Free PMC article.
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Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.
Pan J, Meyers RM, Michel BC, Mashtalir N, Sizemore AE, Wells JN, Cassel SH, Vazquez F, Weir BA, Hahn WC, Marsh JA, Tsherniak A, Kadoch C.
Pan J, et al. Among authors: cassel sh.
Cell Syst. 2018 May 23;6(5):555-568.e7. doi: 10.1016/j.cels.2018.04.011. Epub 2018 May 16.
Cell Syst. 2018.
PMID: 29778836
Free PMC article.
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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes.
Mashtalir N, D'Avino AR, Michel BC, Luo J, Pan J, Otto JE, Zullow HJ, McKenzie ZM, Kubiak RL, St Pierre R, Valencia AM, Poynter SJ, Cassel SH, Ranish JA, Kadoch C.
Mashtalir N, et al. Among authors: cassel sh.
Cell. 2018 Nov 15;175(5):1272-1288.e20. doi: 10.1016/j.cell.2018.09.032. Epub 2018 Oct 18.
Cell. 2018.
PMID: 30343899
Free PMC article.
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Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.
Menotti M, Ambrogio C, Cheong TC, Pighi C, Mota I, Cassel SH, Compagno M, Wang Q, Dall'Olio R, Minero VG, Poggio T, Sharma GG, Patrucco E, Mastini C, Choudhari R, Pich A, Zamo A, Piva R, Giliani S, Mologni L, Collings CK, Kadoch C, Gambacorti-Passerini C, Notarangelo LD, Anton IM, Voena C, Chiarle R.
Menotti M, et al. Among authors: cassel sh.
Nat Med. 2019 Jan;25(1):130-140. doi: 10.1038/s41591-018-0262-9. Epub 2018 Dec 3.
Nat Med. 2019.
PMID: 30510251
Free PMC article.
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ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K.
Klim JR, et al. Among authors: cassel sh.
Nat Neurosci. 2019 Feb;22(2):167-179. doi: 10.1038/s41593-018-0300-4. Epub 2019 Jan 14.
Nat Neurosci. 2019.
PMID: 30643292
Free PMC article.
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Ketamine exposure in early development impairs specification of the primary germ cell layers.
Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K.
Akeju O, et al. Among authors: cassel sh.
Neurotoxicol Teratol. 2014 May-Jun;43:59-68. doi: 10.1016/j.ntt.2014.04.001. Epub 2014 Apr 16.
Neurotoxicol Teratol. 2014.
PMID: 24746641
Free PMC article.
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