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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).
Cheung AK, Hurley B, Kerrigan R, Shu L, Chin DN, Shen Y, O'Brien G, Sung MJ, Hou Y, Axford J, Cody E, Sun R, Fazal A, Fridrich C, Sanchez CC, Tomlinson RC, Jain M, Deng L, Hoffmaster K, Song C, Van Hoosear M, Shin Y, Servais R, Towler C, Hild M, Curtis D, Dietrich WF, Hamann LG, Briner K, Chen KS, Kobayashi D, Sivasankaran R, Dales NA. Cheung AK, et al. Among authors: axford j. J Med Chem. 2018 Dec 27;61(24):11021-11036. doi: 10.1021/acs.jmedchem.8b01291. Epub 2018 Dec 13. J Med Chem. 2018. PMID: 30407821
Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of N-Methyl-5-aryl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators.
Axford J, Sung MJ, Manchester J, Chin D, Jain M, Shin Y, Dix I, Hamann LG, Cheung AK, Sivasankaran R, Briner K, Dales NA, Hurley B. Axford J, et al. J Med Chem. 2021 Apr 22;64(8):4744-4761. doi: 10.1021/acs.jmedchem.0c02173. Epub 2021 Apr 6. J Med Chem. 2021. PMID: 33822618
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Regard JB, Harrison TJ, Axford J, Axford L, Lee L, Ren X, Deng L, Reynolds A, Mao J, Liu Q, Patnaik A, Cohick E, Hollis-Symynkywicz M, Loi S, Riek S, McKeever U, Dunstan D, Sung M, Ware NF, Brown AP, Hamann LG, Marcinkeviciene J, Patterson AW, Marro ML. Regard JB, et al. Among authors: axford j. Biochem Pharmacol. 2023 Mar;209:115418. doi: 10.1016/j.bcp.2023.115418. Epub 2023 Jan 21. Biochem Pharmacol. 2023. PMID: 36693437
The monsoon-associated equine South African pointy mosquito 'Aedes caballus'; the first comprehensive record from southeastern Iran with a description of ecological, morphological, and molecular aspects.
Nejati J, Azari-Hamidian S, Oshaghi MA, Vatandoost H, White VL, Moosa-Kazemi SH, Bueno-Marí R, Hanafi-Bojd AA, Endersby-Harshman NM, Axford JK, Karimian F, Koosha M, Choubdar N, Hoffmann AA. Nejati J, et al. Among authors: axford jk. PLoS One. 2024 May 23;19(5):e0298412. doi: 10.1371/journal.pone.0298412. eCollection 2024. PLoS One. 2024. PMID: 38781219 Free PMC article.
Corrigendum to: "Reducing Unplanned Intubations in the Neonatal Intensive Care Unit After Children's Surgery: A Quality Improvement Project" [J Pediatr Surg 59 (1) (2024 Jan) 45-52].
Juviler P, Meyers JM, Levatino E, Axford J, Barker E, Correll L, Decker AS, Faria J, Gloff M, Loria A, McKenna Benoit M, Schriefer J, Stevens TP, Verna S, Wegman S, Wolcott K, Wakeman D. Juviler P, et al. Among authors: axford j. J Pediatr Surg. 2024 Apr;59(4):747. doi: 10.1016/j.jpedsurg.2024.01.005. Epub 2024 Feb 1. J Pediatr Surg. 2024. PMID: 38307750 No abstract available.
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase.
Hoegenauer K, An S, Axford J, Benander C, Bergsdorf C, Botsch J, Chau S, Fernández C, Gleim S, Hassiepen U, Hunziker J, Joly E, Keller A, Lopez Romero S, Maher R, Mangold AS, Mickanin C, Mihalic M, Neuner P, Patterson AW, Perruccio F, Roggo S, Scesa J, Schröder M, Shkoza D, Thai B, Vulpetti A, Renatus M, Reece-Hoyes JS. Hoegenauer K, et al. Among authors: axford j. ACS Med Chem Lett. 2023 Nov 13;14(12):1631-1639. doi: 10.1021/acsmedchemlett.3c00259. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116426
Reducing Unplanned Intubations in the Neonatal Intensive Care Unit After Children's Surgery: A Quality Improvement Project.
Juviler P, Meyers JM, Levatino E, Axford J, Barker E, Correll L, Decker AS, Faria J, Gloff M, Loria A, McKenna M, Schriefer J, Stevens TP, Verna S, Wegman S, Wolcott K, Wakeman D. Juviler P, et al. Among authors: axford j. J Pediatr Surg. 2024 Jan;59(1):45-52. doi: 10.1016/j.jpedsurg.2023.09.029. Epub 2023 Sep 22. J Pediatr Surg. 2024. PMID: 37845122
Developing Wolbachia-based disease interventions for an extreme environment.
Ross PA, Elfekih S, Collier S, Klein MJ, Lee SS, Dunn M, Jackson S, Zhang Y, Axford JK, Gu X, Home JL, Nassar MS, Paradkar PN, Tawfik EA, Jiggins FM, Almalik AM, Al-Fageeh MB, Hoffmann AA. Ross PA, et al. Among authors: axford jk. PLoS Pathog. 2023 Jan 31;19(1):e1011117. doi: 10.1371/journal.ppat.1011117. eCollection 2023 Jan. PLoS Pathog. 2023. PMID: 36719928 Free PMC article.
122 results