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SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase.
Holt-Danborg L, Vodopiutz J, Nonboe AW, De Laffolie J, Skovbjerg S, Wolters VM, Müller T, Hetzer B, Querfurt A, Zimmer KP, Jensen JK, Entenmann A, Heinz-Erian P, Vogel LK, Janecke AR. Holt-Danborg L, et al. Among authors: jensen jk. Hum Mol Genet. 2019 Mar 1;28(5):828-841. doi: 10.1093/hmg/ddy394. Hum Mol Genet. 2019. PMID: 30445423
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
Larsen BR, Steffensen SD, Nielsen NV, Friis S, Godiksen S, Bornholdt J, Soendergaard C, Nonboe AW, Andersen MN, Poulsen SS, Szabo R, Bugge TH, Lin CY, Skovbjerg H, Jensen JK, Vogel LK. Larsen BR, et al. Among authors: jensen jk. Exp Cell Res. 2013 Apr 1;319(6):918-29. doi: 10.1016/j.yexcr.2013.01.008. Epub 2013 Jan 16. Exp Cell Res. 2013. PMID: 23333561 Free PMC article.
Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs.
Hosseini M, Jiang L, Sørensen HP, Jensen JK, Christensen A, Fogh S, Yuan C, Andersen LM, Huang M, Andreasen PA, Jensen KJ. Hosseini M, et al. Among authors: jensen jk, jensen kj. Mol Pharmacol. 2011 Oct;80(4):585-97. doi: 10.1124/mol.111.072280. Epub 2011 Jun 30. Mol Pharmacol. 2011. PMID: 21719463
261 results