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Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease.
Moss J, Magenheim J, Neiman D, Zemmour H, Loyfer N, Korach A, Samet Y, Maoz M, Druid H, Arner P, Fu KY, Kiss E, Spalding KL, Landesberg G, Zick A, Grinshpun A, Shapiro AMJ, Grompe M, Wittenberg AD, Glaser B, Shemer R, Kaplan T, Dor Y. Moss J, et al. Among authors: grompe m. Nat Commun. 2018 Nov 29;9(1):5068. doi: 10.1038/s41467-018-07466-6. Nat Commun. 2018. PMID: 30498206 Free PMC article.
Identification of tissue-specific cell death using methylation patterns of circulating DNA.
Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y. Lehmann-Werman R, et al. Among authors: grompe m. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. doi: 10.1073/pnas.1519286113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976580 Free PMC article.
Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA.
Lehmann-Werman R, Magenheim J, Moss J, Neiman D, Abraham O, Piyanzin S, Zemmour H, Fox I, Dor T, Grompe M, Landesberg G, Loza BL, Shaked A, Olthoff K, Glaser B, Shemer R, Dor Y. Lehmann-Werman R, et al. Among authors: grompe m. JCI Insight. 2018 Jun 21;3(12):e120687. doi: 10.1172/jci.insight.120687. eCollection 2018 Jun 21. JCI Insight. 2018. PMID: 29925683 Free PMC article.
A DNA methylation atlas of normal human cell types.
Loyfer N, Magenheim J, Peretz A, Cann G, Bredno J, Klochendler A, Fox-Fisher I, Shabi-Porat S, Hecht M, Pelet T, Moss J, Drawshy Z, Amini H, Moradi P, Nagaraju S, Bauman D, Shveiky D, Porat S, Dior U, Rivkin G, Or O, Hirshoren N, Carmon E, Pikarsky A, Khalaileh A, Zamir G, Grinbaum R, Abu Gazala M, Mizrahi I, Shussman N, Korach A, Wald O, Izhar U, Erez E, Yutkin V, Samet Y, Rotnemer Golinkin D, Spalding KL, Druid H, Arner P, Shapiro AMJ, Grompe M, Aravanis A, Venn O, Jamshidi A, Shemer R, Dor Y, Glaser B, Kaplan T. Loyfer N, et al. Among authors: grompe m. Nature. 2023 Jan;613(7943):355-364. doi: 10.1038/s41586-022-05580-6. Epub 2023 Jan 4. Nature. 2023. PMID: 36599988 Free PMC article.
Cell fusion is the principal source of bone-marrow-derived hepatocytes.
Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M. Wang X, et al. Among authors: grompe m. Nature. 2003 Apr 24;422(6934):897-901. doi: 10.1038/nature01531. Epub 2003 Mar 30. Nature. 2003. PMID: 12665832
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice.
Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. Azuma H, et al. Among authors: grompe m. Nat Biotechnol. 2007 Aug;25(8):903-10. doi: 10.1038/nbt1326. Epub 2007 Jul 29. Nat Biotechnol. 2007. PMID: 17664939 Free PMC article.
The ploidy conveyor of mature hepatocytes as a source of genetic variation.
Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, Lenzi ML, Olson SB, Finegold MJ, Grompe M. Duncan AW, et al. Among authors: grompe m. Nature. 2010 Oct 7;467(7316):707-10. doi: 10.1038/nature09414. Epub 2010 Sep 22. Nature. 2010. PMID: 20861837 Free PMC article.
280 results