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The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB. Xiao Y, et al. Among authors: thakkar kn. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19. Proc Natl Acad Sci U S A. 2020. PMID: 32817424 Free PMC article.
Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer.
Miao YR, Thakkar KN, Qian J, Kariolis MS, Huang W, Nandagopal S, Yang TTC, Diep AN, Cherf GM, Xu Y, Moon EJ, Xiao Y, Alemany H, Li T, Yu W, Wei B, Rankin EB, Giaccia AJ. Miao YR, et al. Among authors: thakkar kn. Clin Cancer Res. 2021 Aug 1;27(15):4435-4448. doi: 10.1158/1078-0432.CCR-20-0482. Epub 2021 May 19. Clin Cancer Res. 2021. PMID: 34011561 Free PMC article.
Regulation of gene expression in human cancers by TRIM24.
Appikonda S, Thakkar KN, Barton MC. Appikonda S, et al. Among authors: thakkar kn. Drug Discov Today Technol. 2016 Mar;19:57-63. doi: 10.1016/j.ddtec.2016.05.001. Epub 2016 Aug 10. Drug Discov Today Technol. 2016. PMID: 27769359 Review.
Tissue-specific metabolism and TRIM24.
Thakkar KN, Stratton SA, Craig Barton M. Thakkar KN, et al. Aging (Albany NY). 2015 Oct;7(10):736-7. doi: 10.18632/aging.100822. Aging (Albany NY). 2015. PMID: 26454661 Free PMC article. No abstract available.
TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.
Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC. Pathiraja TN, et al. Among authors: thakkar kn. Oncogene. 2015 May 28;34(22):2836-45. doi: 10.1038/onc.2014.220. Epub 2014 Jul 28. Oncogene. 2015. PMID: 25065590 Free PMC article.
67 results