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USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.
Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M. Laurila PP, et al. Among authors: perttila j. Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015. Sci Transl Med. 2016. PMID: 26819196
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.
Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, Grimard V, Taskinen MR, Thiele C, Salomaa V, Jula A, Perola M, Virtanen I, Peltonen L, Olkkonen VM. Perttilä J, et al. J Mol Med (Berl). 2009 Aug;87(8):825-35. doi: 10.1007/s00109-009-0490-z. Epub 2009 Jun 25. J Mol Med (Berl). 2009. PMID: 19554302 Free PMC article.
Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.
Nidhina Haridas PA, Soronen J, Sädevirta S, Mysore R, Quagliarini F, Pasternack A, Metso J, Perttilä J, Leivonen M, Smas CM, Fischer-Posovszky P, Wabitsch M, Ehnholm C, Ritvos O, Jauhiainen M, Olkkonen VM, Yki-Järvinen H. Nidhina Haridas PA, et al. Among authors: perttila j. J Clin Endocrinol Metab. 2015 Oct;100(10):E1299-307. doi: 10.1210/jc.2015-1254. Epub 2015 Jul 23. J Clin Endocrinol Metab. 2015. PMID: 26204133
Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease.
Soronen J, Yki-Järvinen H, Zhou Y, Sädevirta S, Sarin AP, Leivonen M, Sevastianova K, Perttilä J, Laurila PP, Sigruener A, Schmitz G, Olkkonen VM. Soronen J, et al. Among authors: perttila j. Physiol Rep. 2016 Jan;4(1):e12661. doi: 10.14814/phy2.12661. Physiol Rep. 2016. PMID: 26733244 Free PMC article.
PNPLA3 mediates hepatocyte triacylglycerol remodeling.
Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, Käkelä R, Olkkonen VM. Ruhanen H, et al. Among authors: perttila j. J Lipid Res. 2014 Apr;55(4):739-46. doi: 10.1194/jlr.M046607. Epub 2014 Feb 7. J Lipid Res. 2014. PMID: 24511104 Free PMC article.
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