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A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis.
Kular J, Scheer KG, Pyne NT, Allam AH, Pollard AN, Magenau A, Wright RL, Kolesnikoff N, Moretti PA, Wullkopf L, Stomski FC, Cowin AJ, Woodcock JM, Grimbaldeston MA, Pitson SM, Timpson P, Ramshaw HS, Lopez AF, Samuel MS. Kular J, et al. Among authors: samuel ms. Dev Cell. 2015 Dec 21;35(6):759-74. doi: 10.1016/j.devcel.2015.11.026. Dev Cell. 2015. PMID: 26702834 Free article.
Acute compressive stress activates RHO/ROCK-mediated cellular processes.
Boyle ST, Kular J, Nobis M, Ruszkiewicz A, Timpson P, Samuel MS. Boyle ST, et al. Among authors: samuel ms. Small GTPases. 2020 Sep;11(5):354-370. doi: 10.1080/21541248.2017.1413496. Epub 2018 Feb 17. Small GTPases. 2020. PMID: 29455593 Free PMC article.
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer.
Cazet AS, Hui MN, Elsworth BL, Wu SZ, Roden D, Chan CL, Skhinas JN, Collot R, Yang J, Harvey K, Johan MZ, Cooper C, Nair R, Herrmann D, McFarland A, Deng N, Ruiz-Borrego M, Rojo F, Trigo JM, Bezares S, Caballero R, Lim E, Timpson P, O'Toole S, Watkins DN, Cox TR, Samuel MS, Martín M, Swarbrick A. Cazet AS, et al. Among authors: samuel ms. Nat Commun. 2018 Jul 24;9(1):2897. doi: 10.1038/s41467-018-05220-6. Nat Commun. 2018. PMID: 30042390 Free PMC article. Clinical Trial.
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.
Boyle ST, Poltavets V, Kular J, Pyne NT, Sandow JJ, Lewis AC, Murphy KJ, Kolesnikoff N, Moretti PAB, Tea MN, Tergaonkar V, Timpson P, Pitson SM, Webb AI, Whitfield RJ, Lopez AF, Kochetkova M, Samuel MS. Boyle ST, et al. Among authors: samuel ms. Nat Cell Biol. 2020 Jul;22(7):882-895. doi: 10.1038/s41556-020-0523-y. Epub 2020 May 25. Nat Cell Biol. 2020. PMID: 32451439
149 results