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A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.
Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL. Cline EN, et al. J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29. J Neurochem. 2019. PMID: 30565253 Free PMC article.
Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.
Sebollela A, Mustata GM, Luo K, Velasco PT, Viola KL, Cline EN, Shekhawat GS, Wilcox KC, Dravid VP, Klein WL. Sebollela A, et al. Among authors: cline en. ACS Chem Neurosci. 2014 Dec 17;5(12):1238-45. doi: 10.1021/cn500156r. Epub 2014 Nov 7. ACS Chem Neurosci. 2014. PMID: 25343357 Free PMC article.
A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.
Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL. Sebollela A, et al. Among authors: cline en. J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2. J Neurochem. 2017. PMID: 28670737 Free PMC article.
Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.
Wakeman DR, Weed MR, Perez SE, Cline EN, Viola KL, Wilcox KC, Moddrelle DS, Nisbett EZ, Kurian AM, Bell AF, Pike R, Jacobson PB, Klein WL, Mufson EJ, Lawrence MS, Elsworth JD. Wakeman DR, et al. Among authors: cline en. Neuropathol Appl Neurobiol. 2022 Jun;48(4):e12800. doi: 10.1111/nan.12800. Epub 2022 Mar 2. Neuropathol Appl Neurobiol. 2022. PMID: 35156715 Free PMC article.
16 results