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A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.
Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL. Cline EN, et al. Among authors: klein wl. J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29. J Neurochem. 2019. PMID: 30565253 Free PMC article.
A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.
Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL. Sebollela A, et al. Among authors: klein wl. J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2. J Neurochem. 2017. PMID: 28670737 Free PMC article.
An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis.
Bartley SC, Proctor MT, Xia H, Ho E, Kang DS, Schuster K, Bicca MA, Seckler HS, Viola KL, Patrie SM, Kelleher NL, De Mello FG, Klein WL. Bartley SC, et al. Among authors: klein wl. Int J Mol Sci. 2022 Feb 17;23(4):2208. doi: 10.3390/ijms23042208. Int J Mol Sci. 2022. PMID: 35216328 Free PMC article.
Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.
Sebollela A, Mustata GM, Luo K, Velasco PT, Viola KL, Cline EN, Shekhawat GS, Wilcox KC, Dravid VP, Klein WL. Sebollela A, et al. Among authors: klein wl. ACS Chem Neurosci. 2014 Dec 17;5(12):1238-45. doi: 10.1021/cn500156r. Epub 2014 Nov 7. ACS Chem Neurosci. 2014. PMID: 25343357 Free PMC article.
Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. Pitt J, et al. Among authors: klein wl. Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9. Mol Biol Cell. 2017. PMID: 28963439 Free PMC article.
180 results