Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.
Segraves EN, Holman TR.
Segraves EN, et al.
Biochemistry. 2003 May 13;42(18):5236-43. doi: 10.1021/bi0273462.
Biochemistry. 2003.
PMID: 12731864
The (D)k(cat)/K(M) for 15-hLO, however, was temperature-dependent, consistent with our previous results [Lewis, E. R., Johansen, E., and Holman, T. R. (1999) J. Am. Chem. Soc. 121, 1395-1396], indicating multiple rate-limiting steps. ...
The (D)k(cat)/K(M) for 15-hLO, however, was temperature-dependent, consistent with our previous results [Lewis, E. R., Johansen, E., and …