Aerts JMFG - Search Results

1

In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling.

Kuo CL, Kallemeijn WW, Lelieveld LT, Mirzaian M, Zoutendijk I, Vardi A, Futerman AH, Meijer AH, Spaink HP, Overkleeft HS, Aerts JMFG, Artola M. Kuo CL, et al. Among authors: aerts jmfg. FEBS J. 2019 Feb;286(3):584-600. doi: 10.1111/febs.14744. Epub 2019 Feb 2. FEBS J. 2019. PMID: 30600575 Free PMC article.

2

Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase.

Overkleeft HS, Renkema GH, Neele J, Vianello P, Hung IO, Strijland A, van der Burg AM, Koomen GJ, Pandit UK, Aerts JM. Overkleeft HS, et al. J Biol Chem. 1998 Oct 9;273(41):26522-7. doi: 10.1074/jbc.273.41.26522. J Biol Chem. 1998. PMID: 9756888 Free article.

3

Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, Overkleeft HS. Wennekes T, et al. J Org Chem. 2007 Feb 16;72(4):1088-97. doi: 10.1021/jo061280p. Epub 2007 Jan 23. J Org Chem. 2007. PMID: 17243712

4

N-azidoacetylmannosamine-mediated chemical tagging of gangliosides.

Bussink AP, van Swieten PF, Ghauharali K, Scheij S, van Eijk M, Wennekes T, van der Marel GA, Boot RG, Aerts JM, Overkleeft HS. Bussink AP, et al. J Lipid Res. 2007 Jun;48(6):1417-21. doi: 10.1194/jlr.C700006-JLR200. Epub 2007 Mar 27. J Lipid Res. 2007. PMID: 17392268 Free article.

5

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

Aerts JM, Groener JE, Kuiper S, Donker-Koopman WE, Strijland A, Ottenhoff R, van Roomen C, Mirzaian M, Wijburg FA, Linthorst GE, Vedder AC, Rombach SM, Cox-Brinkman J, Somerharju P, Boot RG, Hollak CE, Brady RO, Poorthuis BJ. Aerts JM, et al. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2812-7. doi: 10.1073/pnas.0712309105. Epub 2008 Feb 19. Proc Natl Acad Sci U S A. 2008. PMID: 18287059 Free PMC article.

6

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.

Bussink AP, Verhoek M, Vreede J, Ghauharali-van der Vlugt K, Donker-Koopman WE, Sprenger RR, Hollak CE, Aerts JM, Boot RG. Bussink AP, et al. FEBS J. 2009 Oct;276(19):5678-88. doi: 10.1111/j.1742-4658.2009.07259.x. Epub 2009 Sep 2. FEBS J. 2009. PMID: 19725875 Free article.

7

Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, Overkleeft HS. Risseeuw MD, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. doi: 10.1016/j.bmcl.2009.10.022. Epub 2009 Oct 8. Bioorg Med Chem Lett. 2009. PMID: 19853441

8

Glycosphingolipids--nature, function, and pharmacological modulation.

Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM. Wennekes T, et al. Angew Chem Int Ed Engl. 2009;48(47):8848-69. doi: 10.1002/anie.200902620. Angew Chem Int Ed Engl. 2009. PMID: 19862781 Review.

9

Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.

van Scherpenzeel M, van den Berg RJ, Donker-Koopman WE, Liskamp RM, Aerts JM, Overkleeft HS, Pieters RJ. van Scherpenzeel M, et al. Bioorg Med Chem. 2010 Jan 1;18(1):267-73. doi: 10.1016/j.bmc.2009.10.060. Epub 2009 Oct 31. Bioorg Med Chem. 2010. PMID: 19931460

10

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.

Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM. Wennekes T, et al. J Med Chem. 2010 Jan 28;53(2):689-98. doi: 10.1021/jm901281m. J Med Chem. 2010. PMID: 20000679

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