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Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C. Parhizkar S, et al. Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7. Nat Neurosci. 2019. PMID: 30617257 Free PMC article.
Inhibition of amyloid-β plaque formation by α-synuclein.
Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Bachhuber T, et al. Nat Med. 2015 Jul;21(7):802-7. doi: 10.1038/nm.3885. Epub 2015 Jun 22. Nat Med. 2015. PMID: 26099047
Aβ oligomers trigger and accelerate Aβ seeding.
Katzmarski N, Ziegler-Waldkirch S, Scheffler N, Witt C, Abou-Ajram C, Nuscher B, Prinz M, Haass C, Meyer-Luehmann M. Katzmarski N, et al. Brain Pathol. 2020 Jan;30(1):36-45. doi: 10.1111/bpa.12734. Epub 2019 Jun 5. Brain Pathol. 2020. PMID: 31099449 Free PMC article.
Microglia contribute to the propagation of Aβ into unaffected brain tissue.
d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M. d'Errico P, et al. Among authors: meyer luehmann m. Nat Neurosci. 2022 Jan;25(1):20-25. doi: 10.1038/s41593-021-00951-0. Epub 2021 Nov 22. Nat Neurosci. 2022. PMID: 34811521 Free PMC article.
46 results