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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Lourenco MV, et al. Nat Med. 2019 Jan;25(1):165-175. doi: 10.1038/s41591-018-0275-4. Epub 2019 Jan 7. Nat Med. 2019. PMID: 30617325 Free PMC article.
The clinical-radiological paradox in multiple sclerosis: myth or truth?
Hartmann A, Noro F, Bahia PRV, Fontes-Dantas FL, Andreiuolo RF, Lopes FCR, Pereira VCSR, Coutinho RA, Araujo AD, Marchiori E, Alves-Leon SV. Hartmann A, et al. Arq Neuropsiquiatr. 2023 Jan;81(1):55-61. doi: 10.1055/s-0042-1758457. Epub 2023 Mar 14. Arq Neuropsiquiatr. 2023. PMID: 36918008 Free PMC article.
Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens.
França LC, Fontes-Dantas FL, Garcia DG, de Araújo AD, da Costa Gonçalves JP, Rêgo CCDS, da Silva EV, do Nascimento OJM, Lopes FCR, Herlinger AL, de Aguiar RS, da Costa Ferreira Junior O, Figueira FFA, de Souza JPBM, De Mesquita JF, Alves-Leon SV. França LC, et al. Among authors: alves leon sv. Arq Neuropsiquiatr. 2023 Apr;81(4):357-368. doi: 10.1055/s-0043-1768698. Epub 2023 May 9. Arq Neuropsiquiatr. 2023. PMID: 37160141 Free PMC article.
Amyloid-β oligomers induce differential gene expression in adult human brain slices.
Sebollela A, Freitas-Correa L, Oliveira FF, Paula-Lima AC, Saraiva LM, Martins SM, Mota LD, Torres C, Alves-Leon S, de Souza JM, Carraro DM, Brentani H, De Felice FG, Ferreira ST. Sebollela A, et al. J Biol Chem. 2012 Mar 2;287(10):7436-45. doi: 10.1074/jbc.M111.298471. Epub 2012 Jan 10. J Biol Chem. 2012. PMID: 22235132 Free PMC article. Clinical Trial.
Astrocyte-induced synaptogenesis is mediated by transforming growth factor β signaling through modulation of D-serine levels in cerebral cortex neurons.
Diniz LP, Almeida JC, Tortelli V, Vargas Lopes C, Setti-Perdigão P, Stipursky J, Kahn SA, Romão LF, de Miranda J, Alves-Leon SV, de Souza JM, Castro NG, Panizzutti R, Gomes FC. Diniz LP, et al. J Biol Chem. 2012 Nov 30;287(49):41432-45. doi: 10.1074/jbc.M112.380824. Epub 2012 Oct 10. J Biol Chem. 2012. PMID: 23055518 Free PMC article.
Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.
Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST. Brito-Moreira J, et al. J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283575 Free PMC article.
Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.
Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra E Silva NM, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alves-Leon S, Marcondes J, Assirati JA Jr, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A. Mendes ND, et al. J Neurosci Methods. 2018 Sep 1;307:203-209. doi: 10.1016/j.jneumeth.2018.05.021. Epub 2018 May 31. J Neurosci Methods. 2018. PMID: 29859877
111 results