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Mutational signatures associated with tobacco smoking in human cancer.
Alexandrov LB, Ju YS, Haase K, Van Loo P, Martincorena I, Nik-Zainal S, Totoki Y, Fujimoto A, Nakagawa H, Shibata T, Campbell PJ, Vineis P, Phillips DH, Stratton MR. Alexandrov LB, et al. Science. 2016 Nov 4;354(6312):618-622. doi: 10.1126/science.aag0299. Science. 2016. PMID: 27811275 Free PMC article.
The Association of Modifiable Breast Cancer Risk Factors and Somatic Genomic Alterations in Breast Tumors: The Cancer Genome Atlas Network.
Heng YJ, Hankinson SE, Wang J, Alexandrov LB, Ambrosone CB, de Andrade VP, Brufsky AM, Couch FJ, King TA, Modugno F, Vachon CM, Eliassen AH, Tamimi RM, Kraft P. Heng YJ, et al. Among authors: alexandrov lb. Cancer Epidemiol Biomarkers Prev. 2020 Mar;29(3):599-605. doi: 10.1158/1055-9965.EPI-19-1087. Epub 2020 Jan 13. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 31932411 Free PMC article.
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. Jiang Q, et al. Among authors: alexandrov lb. Cell Rep. 2021 Jan 26;34(4):108670. doi: 10.1016/j.celrep.2020.108670. Cell Rep. 2021. PMID: 33503434 Free PMC article.
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Bergstrom EN, Luebeck J, Petljak M, Khandekar A, Barnes M, Zhang T, Steele CD, Pillay N, Landi MT, Bafna V, Mischel PS, Harris RS, Alexandrov LB. Bergstrom EN, et al. Among authors: alexandrov lb. Nature. 2022 Feb;602(7897):510-517. doi: 10.1038/s41586-022-04398-6. Epub 2022 Feb 9. Nature. 2022. PMID: 35140399 Free PMC article.
Clock-like mutational processes in human somatic cells.
Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, Stratton MR. Alexandrov LB, et al. Nat Genet. 2015 Dec;47(12):1402-7. doi: 10.1038/ng.3441. Epub 2015 Nov 9. Nat Genet. 2015. PMID: 26551669 Free PMC article.
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.
Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB, Rahbari R, Wedge DC, Davies HR, Ramakrishna M, Fullam A, Martin S, Alder C, Patel N, Gamble S, O'Meara S, Giri DD, Sauer T, Pinder SE, Purdie CA, Borg Å, Stunnenberg H, van de Vijver M, Tan BK, Caldas C, Tutt A, Ueno NT, van 't Veer LJ, Martens JW, Sotiriou C, Knappskog S, Span PN, Lakhani SR, Eyfjörd JE, Børresen-Dale AL, Richardson A, Thompson AM, Viari A, Hurles ME, Nik-Zainal S, Campbell PJ, Stratton MR. Ju YS, et al. Among authors: alexandrov lb. Nature. 2017 Mar 30;543(7647):714-718. doi: 10.1038/nature21703. Epub 2017 Mar 22. Nature. 2017. PMID: 28329761 Free PMC article.
Intra-tumour diversification in colorectal cancer at the single-cell level.
Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble SJ, Alder C, van de Wetering M, Campbell PJ, Stratton MR, Clevers H. Roerink SF, et al. Among authors: alexandrov lb. Nature. 2018 Apr;556(7702):457-462. doi: 10.1038/s41586-018-0024-3. Epub 2018 Apr 11. Nature. 2018. PMID: 29643510
207 results