Buchman VL - Search Results

1

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles.

An H, Skelt L, Notaro A, Highley JR, Fox AH, La Bella V, Buchman VL, Shelkovnikova TA. An H, et al. Among authors: buchman vl. Acta Neuropathol Commun. 2019 Jan 14;7(1):7. doi: 10.1186/s40478-019-0658-x. Acta Neuropathol Commun. 2019. PMID: 30642400 Free PMC article.

2

Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds.

Bachurin SO, Ustyugov AA, Peters O, Shelkovnikova TA, Buchman VL, Ninkina NN. Bachurin SO, et al. Among authors: buchman vl. Dokl Biochem Biophys. 2009 Sep-Oct;428:235-8. doi: 10.1134/s1607672909050032. Dokl Biochem Biophys. 2009. PMID: 20848907 No abstract available.

3

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

Shelkovnikova TA, Ustyugov AA, Millership S, Peters O, Anichtchik O, Spillantini MG, Buchman VL, Bachurin SO, Ninkina NN. Shelkovnikova TA, et al. Among authors: buchman vl. Neurodegener Dis. 2011;8(6):430-7. doi: 10.1159/000324989. Epub 2011 May 12. Neurodegener Dis. 2011. PMID: 21576917 Free PMC article.

4

FUS gene mutations associated with familiar forms of amyotrophic lateral sclerosis affect cellular localization and aggregation properties of the encoded protein.

Shelkovnikova TA, Ustyugov AA, Smirnov AP, Skvortsova VI, Buchman VL, Bachurin SO, Ninkina NN. Shelkovnikova TA, et al. Among authors: buchman vl. Dokl Biochem Biophys. 2011 May-Jun;438:123-6. doi: 10.1134/S1607672911030045. Epub 2011 Jul 3. Dokl Biochem Biophys. 2011. PMID: 21725888 No abstract available.

5

Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.

Bachurin SO, Shelkovnikova TA, Ustyugov AA, Peters O, Khritankova I, Afanasieva MA, Tarasova TV, Alentov II, Buchman VL, Ninkina NN. Bachurin SO, et al. Among authors: buchman vl. Neurotox Res. 2012 Jul;22(1):33-42. doi: 10.1007/s12640-011-9299-y. Epub 2011 Dec 17. Neurotox Res. 2012. PMID: 22179976 Free PMC article.

6

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis.

Peters OM, Millership S, Shelkovnikova TA, Soto I, Keeling L, Hann A, Marsh-Armstrong N, Buchman VL, Ninkina N. Peters OM, et al. Among authors: buchman vl. Neurobiol Dis. 2012 Oct;48(1):124-31. doi: 10.1016/j.nbd.2012.06.016. Epub 2012 Jun 30. Neurobiol Dis. 2012. PMID: 22750530 Free PMC article.

7

Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo.

Ustyugov AA, Shelkovnikova TA, Kokhan VS, Khritankova IV, Peters O, Buchman VL, Bachurin SO, Ninkina NN. Ustyugov AA, et al. Among authors: buchman vl. Bull Exp Biol Med. 2012 Apr;152(6):731-3. doi: 10.1007/s10517-012-1618-7. Bull Exp Biol Med. 2012. PMID: 22803176 English, Russian.

8

Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice.

Peters OM, Shelkovnikova T, Tarasova T, Springe S, Kukharsky MS, Smith GA, Brooks S, Kozin SA, Kotelevtsev Y, Bachurin SO, Ninkina N, Buchman VL. Peters OM, et al. Among authors: buchman vl. J Alzheimers Dis. 2013;36(3):589-96. doi: 10.3233/JAD-130071. J Alzheimers Dis. 2013. PMID: 23645096

9

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.

Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN. Shelkovnikova TA, et al. Among authors: buchman vl. J Biol Chem. 2013 Aug 30;288(35):25266-25274. doi: 10.1074/jbc.M113.492017. Epub 2013 Jul 18. J Biol Chem. 2013. PMID: 23867462 Free PMC article.

10

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm.

Shelkovnikova TA, Robinson HK, Connor-Robson N, Buchman VL. Shelkovnikova TA, et al. Among authors: buchman vl. Cell Cycle. 2013 Oct 1;12(19):3194-202. doi: 10.4161/cc.26241. Epub 2013 Sep 4. Cell Cycle. 2013. PMID: 24013423 Free PMC article.

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