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Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A. Shindo N, et al. Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14. Nat Chem Biol. 2019. PMID: 30643284
Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.
Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S. Matsunaga N, et al. Among authors: shindo n. EBioMedicine. 2016 Nov;13:262-273. doi: 10.1016/j.ebiom.2016.10.008. Epub 2016 Oct 6. EBioMedicine. 2016. PMID: 27745900 Free PMC article.
Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M. Nishimura A, et al. Among authors: shindo n. Sci Signal. 2018 Nov 13;11(556):eaat5185. doi: 10.1126/scisignal.aat5185. Sci Signal. 2018. PMID: 30425165
Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.
Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono M, Ojida A. Sato M, et al. Among authors: shindo n. ACS Med Chem Lett. 2020 Apr 8;11(6):1137-1144. doi: 10.1021/acsmedchemlett.9b00574. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32550993 Free PMC article.
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T, Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A. Hirose Y, et al. Among authors: shindo n. J Med Chem. 2022 Oct 27;65(20):13852-13865. doi: 10.1021/acs.jmedchem.2c01081. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36229406
182 results