Kim RQ - Search Results

1

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

Kim RQ, Geurink PP, Mulder MPC, Fish A, Ekkebus R, El Oualid F, van Dijk WJ, van Dalen D, Ovaa H, van Ingen H, Sixma TK. Kim RQ, et al. Nat Commun. 2019 Jan 16;10(1):231. doi: 10.1038/s41467-018-08231-5. Nat Commun. 2019. PMID: 30651545 Free PMC article.

2

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role.

Kim RQ, van Dijk WJ, Sixma TK. Kim RQ, et al. J Struct Biol. 2016 Jul;195(1):11-8. doi: 10.1016/j.jsb.2016.05.005. Epub 2016 May 13. J Struct Biol. 2016. PMID: 27183903 Free article.

3

Regulation of USP7: A High Incidence of E3 Complexes.

Kim RQ, Sixma TK. Kim RQ, et al. J Mol Biol. 2017 Nov 10;429(22):3395-3408. doi: 10.1016/j.jmb.2017.05.028. Epub 2017 Jun 4. J Mol Biol. 2017. PMID: 28591556 Free article. Review.

4

Quantitative analysis of USP activity in vitro.

Dharadhar S, Kim RQ, Uckelmann M, Sixma TK. Dharadhar S, et al. Among authors: kim rq. Methods Enzymol. 2019;618:281-319. doi: 10.1016/bs.mie.2018.12.023. Epub 2019 Feb 23. Methods Enzymol. 2019. PMID: 30850056

5

Synthesis of Stable NAD⁺ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC.

Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codée JDC, Filippov DV, van der Heden van Noort GJ. Madern JM, et al. Among authors: kim rq. Chembiochem. 2020 Oct 15;21(20):2903-2907. doi: 10.1002/cbic.202000230. Epub 2020 Jun 16. Chembiochem. 2020. PMID: 32421893 Free PMC article.

6

Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.

Kim RQ, Misra M, Gonzalez A, Tomašković I, Shin D, Schindelin H, Filippov DV, Ovaa H, Đikić I, van der Heden van Noort GJ. Kim RQ, et al. Chemistry. 2021 Feb 1;27(7):2506-2512. doi: 10.1002/chem.202004590. Epub 2020 Dec 23. Chemistry. 2021. PMID: 33075184 Free PMC article.

7

Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease.

Mons E, Kim RQ, van Doodewaerd BR, van Veelen PA, Mulder MPC, Ovaa H. Mons E, et al. Among authors: kim rq. J Am Chem Soc. 2021 May 5;143(17):6423-6433. doi: 10.1021/jacs.0c10513. Epub 2021 Apr 22. J Am Chem Soc. 2021. PMID: 33885283 Free PMC article.

8

A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays Illustrated with Kinetic Simulations.

Mons E, Roet S, Kim RQ, Mulder MPC. Mons E, et al. Among authors: kim rq. Curr Protoc. 2022 Jun;2(6):e419. doi: 10.1002/cpz1.419. Curr Protoc. 2022. PMID: 35671150

9

Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.

Jia Y, Kim RQ, Kooij R, Ovaa H, Sapmaz A, Geurink PP. Jia Y, et al. Among authors: kim rq. J Med Chem. 2022 Oct 13;65(19):13288-13304. doi: 10.1021/acs.jmedchem.2c01113. Epub 2022 Sep 23. J Med Chem. 2022. PMID: 36149939 Free PMC article.

10

Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes.

van Tol BDM, van Doodewaerd BR, Lageveen-Kammeijer GSM, Jansen BC, Talavera Ormeño CMP, Hekking PJM, Sapmaz A, Kim RQ, Moutsiopoulou A, Komander D, Wuhrer M, van der Heden van Noort GJ, Ovaa H, Geurink PP. van Tol BDM, et al. Among authors: kim rq. Nat Commun. 2023 Mar 25;14(1):1661. doi: 10.1038/s41467-023-37363-6. Nat Commun. 2023. PMID: 36966155 Free PMC article.

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