Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data.
Kim MT, Huang R, Sedykh A, Wang W, Xia M, Zhu H.
Kim MT, et al. Among authors: sedykh a.
Environ Health Perspect. 2016 May;124(5):634-41. doi: 10.1289/ehp.1509763. Epub 2015 Sep 18.
Environ Health Perspect. 2016.
PMID: 26383846
Free PMC article.
BACKGROUND: Hepatotoxicity accounts for a substantial number of drugs being withdrawn from the market. ...CONCLUSION: Profiling chemical IVIVCs created an opportunity to fully explore the source-to-outcome continuum of modern experimental toxicology using cheminformatics a …
BACKGROUND: Hepatotoxicity accounts for a substantial number of drugs being withdrawn from the market. ...CONCLUSION: Profiling chemi …