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NK cells specifically TCR-dressed to kill cancer cells.
Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre MR, Fåne A, Gaudernack G, Kvalheim G, Myklebust JH, Inderberg EM, Wälchli S. Mensali N, et al. Among authors: hebeisen m. EBioMedicine. 2019 Feb;40:106-117. doi: 10.1016/j.ebiom.2019.01.031. Epub 2019 Jan 18. EBioMedicine. 2019. PMID: 30665853 Free PMC article.
Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.
Schmid DA, Irving MB, Posevitz V, Hebeisen M, Posevitz-Fejfar A, Sarria JC, Gomez-Eerland R, Thome M, Schumacher TN, Romero P, Speiser DE, Zoete V, Michielin O, Rufer N. Schmid DA, et al. Among authors: hebeisen m. J Immunol. 2010 May 1;184(9):4936-46. doi: 10.4049/jimmunol.1000173. Epub 2010 Mar 29. J Immunol. 2010. PMID: 20351194
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.
Rath JA, Bajwa G, Carreres B, Hoyer E, Gruber I, Martínez-Paniagua MA, Yu YR, Nouraee N, Sadeghi F, Wu M, Wang T, Hebeisen M, Rufer N, Varadarajan N, Ho PC, Brenner MK, Gfeller D, Arber C. Rath JA, et al. Among authors: hebeisen m. Sci Adv. 2020 Jul 3;6(27):eaaz7809. doi: 10.1126/sciadv.aaz7809. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32923584 Free PMC article.
TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency.
Allard M, Couturaud B, Carretero-Iglesia L, Duong MN, Schmidt J, Monnot GC, Romero P, Speiser DE, Hebeisen M, Rufer N. Allard M, et al. Among authors: hebeisen m. JCI Insight. 2017 Jul 20;2(14):e92570. doi: 10.1172/jci.insight.92570. eCollection 2017 Jul 20. JCI Insight. 2017. PMID: 28724801 Free PMC article.
44 results