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Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL.
Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C, Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K, Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, Hoermann G, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C. Schmidl C, et al. Among authors: kubicek s. Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28. Nat Chem Biol. 2019. PMID: 30692684 Free PMC article.
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.
Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KVM, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G. Winter GE, et al. Among authors: kubicek s. Nat Chem Biol. 2014 Sep;10(9):768-773. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27. Nat Chem Biol. 2014. PMID: 25064833 Free PMC article.
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
Licciardello MP, Müllner MK, Dürnberger G, Kerzendorfer C, Boidol B, Trefzer C, Sdelci S, Berg T, Penz T, Schuster M, Bock C, Kralovics R, Superti-Furga G, Colinge J, Nijman SM, Kubicek S. Licciardello MP, et al. Among authors: kubicek s. Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29. Oncogene. 2015. PMID: 25263445
Targeting a cell state common to triple-negative breast cancers.
Muellner MK, Mair B, Ibrahim Y, Kerzendorfer C, Lechtermann H, Trefzer C, Klepsch F, Müller AC, Leitner E, Macho-Maschler S, Superti-Furga G, Bennett KL, Baselga J, Rix U, Kubicek S, Colinge J, Serra V, Nijman SM. Muellner MK, et al. Among authors: kubicek s. Mol Syst Biol. 2015 Feb 19;11(1):789. doi: 10.15252/msb.20145664. Mol Syst Biol. 2015. PMID: 25699542 Free PMC article.
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.
Fauster A, Rebsamen M, Huber KV, Bigenzahn JW, Stukalov A, Lardeau CH, Scorzoni S, Bruckner M, Gridling M, Parapatics K, Colinge J, Bennett KL, Kubicek S, Krautwald S, Linkermann A, Superti-Furga G. Fauster A, et al. Among authors: kubicek s. Cell Death Dis. 2015 May 21;6(5):e1767. doi: 10.1038/cddis.2015.130. Cell Death Dis. 2015. PMID: 25996294 Free PMC article.
Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.
Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S. Sdelci S, et al. Among authors: kubicek s. Nat Chem Biol. 2016 Jul;12(7):504-10. doi: 10.1038/nchembio.2080. Epub 2016 May 9. Nat Chem Biol. 2016. PMID: 27159579
103 results