Lorrain DS - Search Results

1

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors.

Rankin KA, Mei F, Kim K, Shen YA, Mayoral SR, Desponts C, Lorrain DS, Green AJ, Baranzini SE, Chan JR, Bove R. Rankin KA, et al. Among authors: lorrain ds. J Neurosci. 2019 Mar 20;39(12):2184-2194. doi: 10.1523/JNEUROSCI.1530-18.2019. Epub 2019 Jan 29. J Neurosci. 2019. PMID: 30696729 Free PMC article.

2

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.

Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. Mei F, et al. Among authors: lorrain ds. J Neurosci. 2016 Jul 27;36(30):7925-35. doi: 10.1523/JNEUROSCI.1493-16.2016. J Neurosci. 2016. PMID: 27466337 Free PMC article.

3

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. Mei F, et al. Among authors: lorrain ds. Elife. 2016 Sep 27;5:e18246. doi: 10.7554/eLife.18246. Elife. 2016. PMID: 27671734 Free PMC article.

4

Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy.

Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ. Cordano C, et al. Brain. 2022 Nov 21;145(11):3943-3952. doi: 10.1093/brain/awac207. Brain. 2022. PMID: 35678509 Free PMC article.

5

A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo.

Messmer D, Lorrain K, Stebbins K, Bravo Y, Stock N, Cabrera G, Correa L, Chen A, Jacintho J, Chiorazzi N, Yan XJ, Spaner D, Prasit P, Lorrain D. Messmer D, et al. Mol Med. 2015 Jun 9;21(1):410-9. doi: 10.2119/molmed.2015.00139. Mol Med. 2015. PMID: 26070013 Free PMC article.

6

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

Lorrain DS, Baccei CS, Bristow LJ, Anderson JJ, Varney MA. Lorrain DS, et al. Neuroscience. 2003;117(3):697-706. doi: 10.1016/s0306-4522(02)00652-8. Neuroscience. 2003. PMID: 12617973

7

In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist.

Stebbins KJ, Broadhead AR, Cabrera G, Correa LD, Messmer D, Bundey R, Baccei C, Bravo Y, Chen A, Stock NS, Prasit P, Lorrain DS. Stebbins KJ, et al. Among authors: lorrain ds. Eur J Pharmacol. 2017 Aug 15;809:130-140. doi: 10.1016/j.ejphar.2017.05.008. Epub 2017 May 5. Eur J Pharmacol. 2017. PMID: 28483457

8

Discovery of PIPE-359, a Brain-Penetrant, Selective M₁ Receptor Antagonist with Robust Efficacy in Murine MOG-EAE.

Schrader TO, Xiong Y, Lorenzana AO, Broadhead A, Stebbins KJ, Poon MM, Baccei C, Lorrain DS. Schrader TO, et al. Among authors: lorrain ds. ACS Med Chem Lett. 2020 Dec 24;12(1):155-161. doi: 10.1021/acsmedchemlett.0c00626. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488977 Free PMC article.

9

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.

Jacintho JD, Baccei CS, Bravo Y, Broadhead A, Chen A, Correa L, Fischer K, Laffitte B, Lee C, Lorrain DS, Messmer D, Prasit P, Stebbins KJ, Stock NS. Jacintho JD, et al. Among authors: lorrain ds. Bioorg Med Chem Lett. 2019 Feb 1;29(3):503-508. doi: 10.1016/j.bmcl.2018.12.045. Epub 2018 Dec 21. Bioorg Med Chem Lett. 2019. PMID: 30594433

10

Identification of the first potent, selective and bioavailable PPARα antagonist.

Bravo Y, Baccei CS, Broadhead A, Bundey R, Chen A, Clark R, Correa L, Jacintho JD, Lorrain DS, Messmer D, Stebbins K, Prasit P, Stock N. Bravo Y, et al. Among authors: lorrain ds. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. doi: 10.1016/j.bmcl.2014.03.090. Epub 2014 Apr 4. Bioorg Med Chem Lett. 2014. PMID: 24745969

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