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The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP. Perucha E, et al. Among authors: frederiksen ks. Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9. Nat Commun. 2019. PMID: 30700717 Free PMC article.
TNF-α blockade induces IL-10 expression in human CD4+ T cells.
Evans HG, Roostalu U, Walter GJ, Gullick NJ, Frederiksen KS, Roberts CA, Sumner J, Baeten DL, Gerwien JG, Cope AP, Geissmann F, Kirkham BW, Taams LS. Evans HG, et al. Among authors: frederiksen ks. Nat Commun. 2014;5:3199. doi: 10.1038/ncomms4199. Nat Commun. 2014. PMID: 24492460 Free PMC article.
Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype.
Povoleri GAM, Lalnunhlimi S, Steel KJA, Agrawal S, O'Byrne AM, Ridley M, Kordasti S, Frederiksen KS, Roberts CA, Taams LS. Povoleri GAM, et al. Among authors: frederiksen ks. Eur J Immunol. 2020 Mar;50(3):445-458. doi: 10.1002/eji.201948190. Epub 2019 Dec 3. Eur J Immunol. 2020. PMID: 31722123 Free PMC article.
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
Puck A, Hopf S, Modak M, Majdic O, Cejka P, Blüml S, Schmetterer K, Arnold-Schrauf C, Gerwien JG, Frederiksen KS, Thell E, Leitner J, Steinberger P, Aigner R, Seyerl-Jiresch M, Zlabinger GJ, Stöckl J. Puck A, et al. Among authors: frederiksen ks. Eur J Immunol. 2017 Jan;47(1):193-205. doi: 10.1002/eji.201646405. Epub 2016 Oct 31. Eur J Immunol. 2017. PMID: 27718235 Free PMC article.
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes.
Shoaib M, Chen Q, Shi X, Nair N, Prasanna C, Yang R, Walter D, Frederiksen KS, Einarsson H, Svensson JP, Liu CF, Ekwall K, Lerdrup M, Nordenskiöld L, Sørensen CS. Shoaib M, et al. Among authors: frederiksen ks. Nat Commun. 2021 Aug 20;12(1):4800. doi: 10.1038/s41467-021-25051-2. Nat Commun. 2021. PMID: 34417450 Free PMC article.
Structure of the glucagon receptor in complex with a glucagon analogue.
Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B. Zhang H, et al. Among authors: frederiksen ks. Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153. Nature. 2018. PMID: 29300013
Evaluating IL-21 as a Potential Therapeutic Target in Crohn's Disease.
Holm TL, Tornehave D, Søndergaard H, Kvist PH, Sondergaard BC, Hansen L, Hermit MB, Holgersen K, Vergo S, Frederiksen KS, Haase C, Lundsgaard D. Holm TL, et al. Among authors: frederiksen ks. Gastroenterol Res Pract. 2018 Apr 10;2018:5962624. doi: 10.1155/2018/5962624. eCollection 2018. Gastroenterol Res Pract. 2018. PMID: 29849593 Free PMC article.
129 results