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SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.
Collij V, Imhann F, Vich Vila A, Fu J, Dijkstra G, Festen EAM, Voskuil MD, Daly MJ, Xavier RJ, Wijmenga C, Zhernakova A, Weersma RK. Collij V, et al. Among authors: wijmenga c. PLoS One. 2019 Jan 31;14(1):e0211328. doi: 10.1371/journal.pone.0211328. eCollection 2019. PLoS One. 2019. PMID: 30703110 Free PMC article.
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.
Monsuur AJ, de Bakker PI, Alizadeh BZ, Zhernakova A, Bevova MR, Strengman E, Franke L, van't Slot R, van Belzen MJ, Lavrijsen IC, Diosdado B, Daly MJ, Mulder CJ, Mearin ML, Meijer JW, Meijer GA, van Oort E, Wapenaar MC, Koeleman BP, Wijmenga C. Monsuur AJ, et al. Among authors: wijmenga c. Nat Genet. 2005 Dec;37(12):1341-4. doi: 10.1038/ng1680. Epub 2005 Nov 13. Nat Genet. 2005. PMID: 16282976
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. de Bakker PI, et al. Among authors: wijmenga c. Nat Genet. 2006 Oct;38(10):1166-72. doi: 10.1038/ng1885. Epub 2006 Sep 24. Nat Genet. 2006. PMID: 16998491 Free PMC article.
Genetic variation in myosin IXB is associated with ulcerative colitis.
van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM, Crusius JB, Annese V, Latiano A, Silverberg MS, Bitton A, Fisher SA, Steinhart AH, Forbes A, Sanderson J, Prescott NJ, Strachan DP, Playford RJ, Mathew CG, Wijmenga C, Daly MJ, Rioux JD, van Heel DA. van Bodegraven AA, et al. Among authors: wijmenga c. Gastroenterology. 2006 Dec;131(6):1768-74. doi: 10.1053/j.gastro.2006.09.011. Epub 2006 Sep 8. Gastroenterology. 2006. PMID: 17087940
The MYO9B gene is a strong risk factor for developing refractory celiac disease.
Wolters VM, Verbeek WH, Zhernakova A, Onland-Moret C, Schreurs MW, Monsuur AJ, Verduijn W, Wijmenga C, Mulder CJ. Wolters VM, et al. Among authors: wijmenga c. Clin Gastroenterol Hepatol. 2007 Dec;5(12):1399-405, 1405.e1-2. doi: 10.1016/j.cgh.2007.08.018. Epub 2007 Oct 29. Clin Gastroenterol Hepatol. 2007. PMID: 17967566
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.
Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, van Heel DA, van der Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C. Zhernakova A, et al. Among authors: wijmenga c. Am J Hum Genet. 2007 Dec;81(6):1284-8. doi: 10.1086/522037. Epub 2007 Oct 24. Am J Hum Genet. 2007. PMID: 17999365 Free PMC article.
704 results