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Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.
Valsesia A, Wang QP, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, Viguerie N, Langin D, Harper ME, Astrup A, Saris WH, Dent R, Neely GG, Hager J. Valsesia A, et al. Among authors: descombes p. Nat Commun. 2019 Feb 1;10(1):540. doi: 10.1038/s41467-019-08492-8. Nat Commun. 2019. PMID: 30710084 Free PMC article.
Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems.
Thevenet J, De Marchi U, Domingo JS, Christinat N, Bultot L, Lefebvre G, Sakamoto K, Descombes P, Masoodi M, Wiederkehr A. Thevenet J, et al. Among authors: descombes p. FASEB J. 2016 May;30(5):1913-26. doi: 10.1096/fj.201500182. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839375
Using single-cell imaging, we observed an acute pronounced reduction of the mitochondrial electrical potential and a concomitant drop of the NAD(P)H signal in astrocytes, but not in neurons. Despite the observed effects on mitochondrial function, MCFAs did not lower intrac …
Using single-cell imaging, we observed an acute pronounced reduction of the mitochondrial electrical potential and a concomitant drop of the …
A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia.
Pannérec A, Springer M, Migliavacca E, Ireland A, Piasecki M, Karaz S, Jacot G, Métairon S, Danenberg E, Raymond F, Descombes P, McPhee JS, Feige JN. Pannérec A, et al. Among authors: descombes p. Aging (Albany NY). 2016 Apr;8(4):712-29. doi: 10.18632/aging.100926. Aging (Albany NY). 2016. PMID: 27019136 Free PMC article.
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
Lukjanenko L, Jung MJ, Hegde N, Perruisseau-Carrier C, Migliavacca E, Rozo M, Karaz S, Jacot G, Schmidt M, Li L, Metairon S, Raymond F, Lee U, Sizzano F, Wilson DH, Dumont NA, Palini A, Fässler R, Steiner P, Descombes P, Rudnicki MA, Fan CM, von Maltzahn J, Feige JN, Bentzinger CF. Lukjanenko L, et al. Among authors: descombes p. Nat Med. 2016 Aug;22(8):897-905. doi: 10.1038/nm.4126. Epub 2016 Jul 4. Nat Med. 2016. PMID: 27376579 Free PMC article.
Transcriptome profiling from adipose tissue during a low-calorie diet reveals predictors of weight and glycemic outcomes in obese, nondiabetic subjects.
Armenise C, Lefebvre G, Carayol J, Bonnel S, Bolton J, Di Cara A, Gheldof N, Descombes P, Langin D, Saris WH, Astrup A, Hager J, Viguerie N, Valsesia A. Armenise C, et al. Among authors: descombes p. Am J Clin Nutr. 2017 Sep;106(3):736-746. doi: 10.3945/ajcn.117.156216. Epub 2017 Aug 9. Am J Clin Nutr. 2017. PMID: 28793995 Free article. Clinical Trial.
Development and evaluation of a genome-wide Coffee 8.5K SNP array and its application for high-density genetic mapping and for investigating the origin of Coffea arabica L.
Merot-L'anthoene V, Tournebize R, Darracq O, Rattina V, Lepelley M, Bellanger L, Tranchant-Dubreuil C, Coulée M, Pégard M, Metairon S, Fournier C, Stoffelen P, Janssens SB, Kiwuka C, Musoli P, Sumirat U, Legnaté H, Kambale JL, Ferreira da Costa Neto J, Revel C, de Kochko A, Descombes P, Crouzillat D, Poncet V. Merot-L'anthoene V, et al. Among authors: descombes p. Plant Biotechnol J. 2019 Jul;17(7):1418-1430. doi: 10.1111/pbi.13066. Epub 2019 Feb 4. Plant Biotechnol J. 2019. PMID: 30582651 Free PMC article.
172 results