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Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.
Valsesia A, Wang QP, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, Viguerie N, Langin D, Harper ME, Astrup A, Saris WH, Dent R, Neely GG, Hager J. Valsesia A, et al. Among authors: lau p. Nat Commun. 2019 Feb 1;10(1):540. doi: 10.1038/s41467-019-08492-8. Nat Commun. 2019. PMID: 30710084 Free PMC article.
Adiposity significantly modifies genetic risk for dyslipidemia.
Cole CB, Nikpay M, Lau P, Stewart AF, Davies RW, Wells GA, Dent R, McPherson R. Cole CB, et al. Among authors: lau p. J Lipid Res. 2014 Nov;55(11):2416-22. doi: 10.1194/jlr.P052522. Epub 2014 Sep 15. J Lipid Res. 2014. PMID: 25225679 Free PMC article.
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism.
Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack RS, Al-Dirbashi OY, Dent R, McPherson R, Harper ME. Thrush AB, et al. Among authors: lau p. Int J Obes (Lond). 2018 Mar;42(3):353-362. doi: 10.1038/ijo.2017.286. Epub 2017 Nov 20. Int J Obes (Lond). 2018. PMID: 29151592 Free PMC article.
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice.
Karunakaran D, Turner AW, Duchez AC, Soubeyrand S, Rasheed A, Smyth D, Cook DP, Nikpay M, Kandiah JW, Pan C, Geoffrion M, Lee R, Boytard L, Wyatt H, Nguyen MA, Lau P, Laakso M, Ramkhelawon B, Alvarez M, Pietiläinen KH, Pajukanta P, Vanderhyden BC, Liu P, Berger SB, Gough PJ, Bertin J, Harper ME, Lusis AJ, McPherson R, Rayner KJ. Karunakaran D, et al. Among authors: lau p. Nat Metab. 2020 Oct;2(10):1113-1125. doi: 10.1038/s42255-020-00279-2. Epub 2020 Sep 28. Nat Metab. 2020. PMID: 32989316 Free PMC article.
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice.
Karunakaran D, Turner AW, Duchez AC, Soubeyrand S, Rasheed A, Smyth D, Cook DP, Nikpay M, Kandiah JW, Pan C, Geoffrion M, Lee R, Boytard L, Wyatt H, Nguyen MA, Lau P, Laakso M, Ramkhelawon B, Alvarez M, Pietiläinen KH, Pajukanta P, Vanderhyden BC, Liu P, Berger SB, Gough PJ, Bertin J, Harper ME, Lusis AJ, McPherson R, Rayner KJ. Karunakaran D, et al. Among authors: lau p. Nat Metab. 2020 Oct;2(10):1181. doi: 10.1038/s42255-020-00309-z. Nat Metab. 2020. PMID: 33033401
919 results