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Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance.
Sørensen AL, Reis CA, Tarp MA, Mandel U, Ramachandran K, Sankaranarayanan V, Schwientek T, Graham R, Taylor-Papadimitriou J, Hollingsworth MA, Burchell J, Clausen H. Sørensen AL, et al. Among authors: mandel u. Glycobiology. 2006 Feb;16(2):96-107. doi: 10.1093/glycob/cwj044. Epub 2005 Oct 5. Glycobiology. 2006. PMID: 16207894
Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat.
Tarp MA, Sørensen AL, Mandel U, Paulsen H, Burchell J, Taylor-Papadimitriou J, Clausen H. Tarp MA, et al. Among authors: mandel u. Glycobiology. 2007 Feb;17(2):197-209. doi: 10.1093/glycob/cwl061. Epub 2006 Oct 18. Glycobiology. 2007. PMID: 17050588
We have recently shown that MUC1 with GalNAcalpha1-O-Ser/Thr (Tn) and NeuAcalpha2-6GalNAcalpha1-O-Ser/Thr (STn) O-glycosylation is a cancer-specific glycoform, and that Tn/STn-MUC1 glycopeptide-based vaccines can override tolerance in human MUC1 transgenic mice and induce humoral …
We have recently shown that MUC1 with GalNAcalpha1-O-Ser/Thr (Tn) and NeuAcalpha2-6GalNAcalpha1-O-Ser/Thr (STn) O-glycosylation is a cancer- …
Seromic profiling of colorectal cancer patients with novel glycopeptide microarray.
Pedersen JW, Blixt O, Bennett EP, Tarp MA, Dar I, Mandel U, Poulsen SS, Pedersen AE, Rasmussen S, Jess P, Clausen H, Wandall HH. Pedersen JW, et al. Among authors: mandel u. Int J Cancer. 2011 Apr 15;128(8):1860-71. doi: 10.1002/ijc.25778. Epub 2011 Jan 12. Int J Cancer. 2011. PMID: 21344374 Free article.
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.
Marcos NT, Bennett EP, Gomes J, Magalhaes A, Gomes C, David L, Dar I, Jeanneau C, DeFrees S, Krustrup D, Vogel LK, Kure EH, Burchell J, Taylor-Papadimitriou J, Clausen H, Mandel U, Reis CA. Marcos NT, et al. Among authors: mandel u. Front Biosci (Elite Ed). 2011 Jun 1;3(4):1443-55. doi: 10.2741/e345. Front Biosci (Elite Ed). 2011. PMID: 21622148 Free article.
Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.
Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H. Schjoldager KT, et al. Among authors: mandel u. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566642 Free PMC article.
128 results