Marugan JJ - Search Results

1

Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus.

Morazzani EM, Compton JR, Leary DH, Berry AV, Hu X, Marugan JJ, Glass PJ, Legler PM. Morazzani EM, et al. Among authors: marugan jj. Antiviral Res. 2019 Apr;164:106-122. doi: 10.1016/j.antiviral.2019.02.001. Epub 2019 Feb 10. Antiviral Res. 2019. PMID: 30742841 Free PMC article.

2

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

Xiao J, Westbroek W, Motabar O, Lea WA, Hu X, Velayati A, Zheng W, Southall N, Gustafson AM, Goldin E, Sidransky E, Liu K, Simeonov A, Tamargo RJ, Ribes A, Matalonga L, Ferrer M, Marugan JJ. Xiao J, et al. Among authors: marugan jj. J Med Chem. 2012 Sep 13;55(17):7546-59. doi: 10.1021/jm3005543. Epub 2012 Aug 17. J Med Chem. 2012. PMID: 22834902 Free PMC article.

3

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay.

Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. Chen CZ, et al. Among authors: marugan jj. J Biomol Screen. 2013 Jul;18(6):670-7. doi: 10.1177/1087057112469406. Epub 2012 Dec 4. J Biomol Screen. 2013. PMID: 23212924 Free PMC article.

4

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

Xiao J, Huang Z, Chen CZ, Agoulnik IU, Southall N, Hu X, Jones RE, Ferrer M, Zheng W, Agoulnik AI, Marugan JJ. Xiao J, et al. Among authors: marugan jj. Nat Commun. 2013;4:1953. doi: 10.1038/ncomms2953. Nat Commun. 2013. PMID: 23764525 Free PMC article.

5

Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.

Xiao J, Free RB, Barnaeva E, Conroy JL, Doyle T, Miller B, Bryant-Genevier M, Taylor MK, Hu X, Dulcey AE, Southall N, Ferrer M, Titus S, Zheng W, Sibley DR, Marugan JJ. Xiao J, et al. Among authors: marugan jj. J Med Chem. 2014 Apr 24;57(8):3450-63. doi: 10.1021/jm500126s. Epub 2014 Apr 10. J Med Chem. 2014. PMID: 24666157 Free PMC article.

6

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ. He S, et al. Among authors: marugan jj. Sci Transl Med. 2015 Apr 8;7(282):282ra49. doi: 10.1126/scitranslmed.3010286. Sci Transl Med. 2015. PMID: 25855495 Free PMC article.

7

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ. He S, et al. Among authors: marugan jj. ACS Comb Sci. 2015 Oct 12;17(10):641-52. doi: 10.1021/acscombsci.5b00101. Epub 2015 Sep 17. ACS Comb Sci. 2015. PMID: 26332742 Free PMC article.

8

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.

Huang Z, Myhr C, Bathgate RA, Ho BA, Bueno A, Hu X, Xiao J, Southall N, Barnaeva E, Agoulnik IU, Marugan JJ, Ferrer M, Agoulnik AI. Huang Z, et al. Among authors: marugan jj. Front Endocrinol (Lausanne). 2015 Aug 17;6:128. doi: 10.3389/fendo.2015.00128. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 26347712 Free PMC article.

9

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ. He S, et al. Among authors: marugan jj. J Med Chem. 2016 Feb 11;59(3):841-53. doi: 10.1021/acs.jmedchem.5b00752. Epub 2016 Feb 1. J Med Chem. 2016. PMID: 26599718 Free PMC article.

10

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.

Hu X, Myhr C, Huang Z, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, Ferrer M, Marugan JJ, Southall N, Agoulnik AI. Hu X, et al. Among authors: marugan jj. Biochemistry. 2016 Mar 29;55(12):1772-83. doi: 10.1021/acs.biochem.5b01195. Epub 2016 Mar 4. Biochemistry. 2016. PMID: 26866459 Free PMC article.

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