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A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.
Rangwala SM, D'Aquino K, Zhang YM, Bader L, Edwards W, Zheng S, Eckardt A, Lacombe A, Pick R, Moreno V, Kang L, Jian W, Arnoult E, Case M, Jenkinson C, Chi E, Swanson RV, Kievit P, Grove K, Macielag M, Erion MD, SinhaRoy R, Leonard JN. Rangwala SM, et al. Among authors: chi e. Cell Metab. 2019 Apr 2;29(4):837-843.e5. doi: 10.1016/j.cmet.2019.01.017. Epub 2019 Feb 14. Cell Metab. 2019. PMID: 30773465 Free PMC article.
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity.
Camacho RC, You S, D'Aquino KE, Li W, Wang Y, Gunnet J, Littrell J, Qi JS, Kang L, Jian W, MacDonald M, Tat T, Steiner D, Zhang YM, Lanter J, Patch R, Zhang R, Li J, Edavettal S, Edwards W, Dinh T, Wang LY, Connor J, Hunter M, Chi E, Swanson RV, Leonard JN, Case MA. Camacho RC, et al. Among authors: chi e. MAbs. 2020 Jan-Dec;12(1):1794687. doi: 10.1080/19420862.2020.1794687. MAbs. 2020. PMID: 32744157 Free PMC article.
Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
Edwards W, Fung-Leung WP, Huang C, Chi E, Wu N, Liu Y, Maher MP, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson RV, Wickenden AD. Edwards W, et al. Among authors: chi e. J Biol Chem. 2014 Aug 15;289(33):22704-22714. doi: 10.1074/jbc.M114.568642. Epub 2014 Jun 17. J Biol Chem. 2014. PMID: 24939846 Free PMC article.
Structural insights into humanization of anti-tissue factor antibody 10H10.
Teplyakov A, Obmolova G, Malia TJ, Raghunathan G, Martinez C, Fransson J, Edwards W, Connor J, Husovsky M, Beck H, Chi E, Fenton S, Zhou H, Almagro JC, Gilliland GL. Teplyakov A, et al. Among authors: chi e. MAbs. 2018 Feb/Mar;10(2):269-277. doi: 10.1080/19420862.2017.1412026. Epub 2018 Jan 2. MAbs. 2018. PMID: 29283291 Free PMC article.
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
Somoza JR, Skene RJ, Katz BA, Mol C, Ho JD, Jennings AJ, Luong C, Arvai A, Buggy JJ, Chi E, Tang J, Sang BC, Verner E, Wynands R, Leahy EM, Dougan DR, Snell G, Navre M, Knuth MW, Swanson RV, McRee DE, Tari LW. Somoza JR, et al. Among authors: chi e. Structure. 2004 Jul;12(7):1325-34. doi: 10.1016/j.str.2004.04.012. Structure. 2004. PMID: 15242608 Free article.
Human framework adaptation of a mouse anti-human IL-13 antibody.
Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, Feng Y, Giles-Komar J, Gilliland G, Lollo B, Malia TJ, Nishioka W, Obmolova G, Zhao S, Zhao Y, Swanson RV, Almagro JC. Fransson J, et al. Among authors: chi e. J Mol Biol. 2010 Apr 30;398(2):214-31. doi: 10.1016/j.jmb.2010.03.004. Epub 2010 Mar 10. J Mol Biol. 2010. PMID: 20226193
Exploring nitrilase sequence space for enantioselective catalysis.
Robertson DE, Chaplin JA, DeSantis G, Podar M, Madden M, Chi E, Richardson T, Milan A, Miller M, Weiner DP, Wong K, McQuaid J, Farwell B, Preston LA, Tan X, Snead MA, Keller M, Mathur E, Kretz PL, Burk MJ, Short JM. Robertson DE, et al. Among authors: chi e. Appl Environ Microbiol. 2004 Apr;70(4):2429-36. doi: 10.1128/AEM.70.4.2429-2436.2004. Appl Environ Microbiol. 2004. PMID: 15066841 Free PMC article.
316 results