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Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer.
Sougiannis AT, VanderVeen B, Chatzistamou I, Kubinak JL, Nagarkatti M, Fan D, Murphy EA. Sougiannis AT, et al. Am J Physiol Gastrointest Liver Physiol. 2022 Mar 1;322(3):G383-G395. doi: 10.1152/ajpgi.00303.2021. Epub 2022 Jan 12. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 35018819 Free PMC article.
High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages.
Bader J, Carson M, Enos R, Velazquez K, Sougiannis A, Singh U, Becker W, Nagarkatti M, Fan D, Murphy A. Bader J, et al. Oncotarget. 2020 Dec 8;11(49):4554-4569. doi: 10.18632/oncotarget.27832. eCollection 2020 Dec 8. Oncotarget. 2020. PMID: 33346251 Free PMC article.
Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments.
Bader JE, Enos RT, Velázquez KT, Carson MS, Sougiannis AT, McGuinness OP, Robinson CM, Murphy EA. Bader JE, et al. Among authors: sougiannis at. Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E358-E372. doi: 10.1152/ajpendo.00438.2018. Epub 2018 Dec 21. Am J Physiol Endocrinol Metab. 2019. PMID: 30576244 Free PMC article.
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