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The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function.
Brial F, Alzaid F, Sonomura K, Kamatani Y, Meneyrol K, Le Lay A, Péan N, Hedjazi L, Sato TA, Venteclef N, Magnan C, Lathrop M, Dumas ME, Matsuda F, Zalloua P, Gauguier D. Brial F, et al. Among authors: le lay a. Cell Rep. 2020 Feb 18;30(7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066. Cell Rep. 2020. PMID: 32075738 Free article.
Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling.
Péan N, Le Lay A, Brial F, Wasserscheid J, Rouch C, Vincent M, Myridakis A, Hedjazi L, Dumas ME, Grundberg E, Lathrop M, Magnan C, Dewar K, Gauguier D. Péan N, et al. Among authors: le lay a. Diabetologia. 2020 Jun;63(6):1223-1235. doi: 10.1007/s00125-020-05122-7. Epub 2020 Mar 16. Diabetologia. 2020. PMID: 32173762 Free PMC article.
Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
Brial F, Chilloux J, Nielsen T, Vieira-Silva S, Falony G, Andrikopoulos P, Olanipekun M, Hoyles L, Djouadi F, Neves AL, Rodriguez-Martinez A, Mouawad GI, Pons N, Forslund S, Le-Chatelier E, Le Lay A, Nicholson J, Hansen T, Hyötyläinen T, Clément K, Oresic M, Bork P, Ehrlich SD, Raes J, Pedersen OB, Gauguier D, Dumas ME. Brial F, et al. Among authors: le lay a. Gut. 2021 Nov;70(11):2105-2114. doi: 10.1136/gutjnl-2020-323314. Epub 2021 May 11. Gut. 2021. PMID: 33975870 Free PMC article.
A clinical-scale BioArtificial Liver, developed for GMP, improved clinical parameters of liver function in porcine liver failure.
Selden C, Bundy J, Erro E, Puschmann E, Miller M, Kahn D, Hodgson H, Fuller B, Gonzalez-Molina J, Le Lay A, Gibbons S, Chalmers S, Modi S, Thomas A, Kilbride P, Isaacs A, Ginsburg R, Ilsley H, Thomson D, Chinnery G, Mankahla N, Loo L, Spearman CW. Selden C, et al. Among authors: le lay a. Sci Rep. 2017 Nov 6;7(1):14518. doi: 10.1038/s41598-017-15021-4. Sci Rep. 2017. PMID: 29109530 Free PMC article.
Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans.
Le Lay A, Philippe E, Roth F, Sanchez-Archidona AR, Mehl F, Denom J, Prasad R, Asplund O, Hansson O, Ibberson M, Andreelli F, Santoro L, Amouyal P, Amouyal G, Brechot C, Jamot L, Cruciani-Guglielmacci C, Magnan C. Le Lay A, et al. Heliyon. 2022 Jul 16;8(7):e09944. doi: 10.1016/j.heliyon.2022.e09944. eCollection 2022 Jul. Heliyon. 2022. PMID: 35874080 Free PMC article.
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