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Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.
Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N. Dalmas E, et al. Among authors: venteclef n. Nat Med. 2015 Jun;21(6):610-8. doi: 10.1038/nm.3829. Epub 2015 May 4. Nat Med. 2015. PMID: 25939064
IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans.
Alzaid F, Lagadec F, Albuquerque M, Ballaire R, Orliaguet L, Hainault I, Blugeon C, Lemoine S, Lehuen A, Saliba DG, Udalova IA, Paradis V, Foufelle F, Venteclef N. Alzaid F, et al. Among authors: venteclef n. JCI Insight. 2016 Dec 8;1(20):e88689. doi: 10.1172/jci.insight.88689. JCI Insight. 2016. PMID: 27942586 Free PMC article.
The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.
Firmin FF, Oger F, Gheeraert C, Dubois-Chevalier J, Vercoutter-Edouart AS, Alzaid F, Mazuy C, Dehondt H, Alexandre J, Derudas B, Dhalluin Q, Ploton M, Berthier A, Woitrain E, Lefebvre T, Venteclef N, Pattou F, Staels B, Eeckhoute J, Lefebvre P. Firmin FF, et al. Among authors: venteclef n. Sci Rep. 2017 Oct 26;7(1):14087. doi: 10.1038/s41598-017-14570-y. Sci Rep. 2017. PMID: 29075020 Free PMC article. Clinical Trial.
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Liang N, et al. Among authors: venteclef n. Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z. Nat Commun. 2019. PMID: 30975991 Free PMC article.
The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function.
Brial F, Alzaid F, Sonomura K, Kamatani Y, Meneyrol K, Le Lay A, Péan N, Hedjazi L, Sato TA, Venteclef N, Magnan C, Lathrop M, Dumas ME, Matsuda F, Zalloua P, Gauguier D. Brial F, et al. Among authors: venteclef n. Cell Rep. 2020 Feb 18;30(7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066. Cell Rep. 2020. PMID: 32075738 Free article.
78 results