Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems.
Thevenet J, De Marchi U, Domingo JS, Christinat N, Bultot L, Lefebvre G, Sakamoto K, Descombes P, Masoodi M, Wiederkehr A.
Thevenet J, et al. Among authors: wiederkehr a.
FASEB J. 2016 May;30(5):1913-26. doi: 10.1096/fj.201500182. Epub 2016 Feb 2.
FASEB J. 2016.
PMID: 26839375
Using single-cell imaging, we observed an acute pronounced reduction of the mitochondrial electrical potential and a concomitant drop of the NAD(P)H signal in astrocytes, but not in neurons. ...-Thevenet, J., De Marchi, U., Santo Domingo, J., Christinat, N., Bultot, L., Le …
Using single-cell imaging, we observed an acute pronounced reduction of the mitochondrial electrical potential and a concomitant drop …