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Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix.
Bacon J, Alderwick LJ, Allnutt JA, Gabasova E, Watson R, Hatch KA, Clark SO, Jeeves RE, Marriott A, Rayner E, Tolley H, Pearson G, Hall G, Besra GS, Wernisch L, Williams A, Marsh PD. Bacon J, et al. PLoS One. 2014 Feb 6;9(2):e87329. doi: 10.1371/journal.pone.0087329. eCollection 2014. PLoS One. 2014. PMID: 24516549 Free PMC article.
Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315.
Jeeves RE, Marriott AA, Pullan ST, Hatch KA, Allnutt JC, Freire-Martin I, Hendon-Dunn CL, Watson R, Witney AA, Tyler RH, Arnold C, Marsh PD, McHugh TD, Bacon J. Jeeves RE, et al. Among authors: bacon j. PLoS One. 2015 Sep 18;10(9):e0138253. doi: 10.1371/journal.pone.0138253. eCollection 2015. PLoS One. 2015. PMID: 26382066 Free PMC article.
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon CW, Jeeves RE, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova Y, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N. Mosaei H, et al. Among authors: bacon j. Mol Cell. 2018 Oct 18;72(2):263-274.e5. doi: 10.1016/j.molcel.2018.08.028. Epub 2018 Sep 20. Mol Cell. 2018. PMID: 30244835 Free PMC article.
Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly.
Cui Y, Lanne A, Peng X, Browne E, Bhatt A, Coltman NJ, Craven P, Cox LR, Cundy NJ, Dale K, Feula A, Frampton J, Fung M, Morton M, Goff A, Salih M, Lang X, Li X, Moon C, Pascoe J, Portman V, Press C, Schulz-Utermoehl T, Lee S, Tortorella MD, Tu Z, Underwood ZE, Wang C, Yoshizawa A, Zhang T, Waddell SJ, Bacon J, Alderwick L, Fossey JS, Neagoie C. Cui Y, et al. Among authors: bacon j. J Med Chem. 2024 Feb 22;67(4):2529-2548. doi: 10.1021/acs.jmedchem.3c01643. Epub 2024 Feb 8. J Med Chem. 2024. PMID: 38331432 Free PMC article.
505 results