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Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation.
Abdulhay NJ, Fiorini C, Verboon JM, Ludwig LS, Ulirsch JC, Zieger B, Lareau CA, Mi X, Roy A, Obeng EA, Erlacher M, Gupta N, Gabriel SB, Ebert BL, Niemeyer CM, Khoriaty RN, Ancliff P, Gazda HT, Wlodarski MW, Sankaran VG. Abdulhay NJ, et al. Among authors: roy a. J Exp Med. 2019 May 6;216(5):1050-1060. doi: 10.1084/jem.20181625. Epub 2019 Mar 26. J Exp Med. 2019. PMID: 30914438 Free PMC article.
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
Louka E, Povinelli B, Rodriguez-Meira A, Buck G, Wen WX, Wang G, Sousos N, Ashley N, Hamblin A, Booth CAG, Roy A, Elliott N, Iskander D, de la Fuente J, Fordham N, O'Byrne S, Inglott S, Norfo R, Salio M, Thongjuea S, Rao A, Roberts I, Mead AJ. Louka E, et al. Among authors: roy a. J Exp Med. 2021 Feb 1;218(2):e20180853. doi: 10.1084/jem.20180853. J Exp Med. 2021. PMID: 33416891 Free PMC article.
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA. Godfrey L, et al. Among authors: roy a. Leukemia. 2021 Jan;35(1):90-106. doi: 10.1038/s41375-020-0808-y. Epub 2020 Apr 2. Leukemia. 2021. PMID: 32242051 Free PMC article.
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Rice S, Jackson T, Crump NT, Fordham N, Elliott N, O'Byrne S, Fanego MDML, Addy D, Crabb T, Dryden C, Inglott S, Ladon D, Wright G, Bartram J, Ancliff P, Mead AJ, Halsey C, Roberts I, Milne TA, Roy A. Rice S, et al. Among authors: roy a. Nat Commun. 2021 Nov 25;12(1):6905. doi: 10.1038/s41467-021-27270-z. Nat Commun. 2021. PMID: 34824279 Free PMC article.
GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.
Roberts I, Alford K, Hall G, Juban G, Richmond H, Norton A, Vallance G, Perkins K, Marchi E, McGowan S, Roy A, Cowan G, Anthony M, Gupta A, Ho J, Uthaya S, Curley A, Rasiah SV, Watts T, Nicholl R, Bedford-Russell A, Blumberg R, Thomas A, Gibson B, Halsey C, Lee PW, Godambe S, Sweeney C, Bhatnagar N, Goriely A, Campbell P, Vyas P; Oxford-Imperial Down Syndrome Cohort Study Group. Roberts I, et al. Among authors: roy a. Blood. 2013 Dec 5;122(24):3908-17. doi: 10.1182/blood-2013-07-515148. Epub 2013 Sep 10. Blood. 2013. PMID: 24021668 Free PMC article.
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Muskens IS, Li S, Jackson T, Elliot N, Hansen HM, Myint SS, Pandey P, Schraw JM, Roy R, Anguiano J, Goudevenou K, Siegmund KD, Lupo PJ, de Bruijn MFTR, Walsh KM, Vyas P, Ma X, Roy A, Roberts I, Wiemels JL, de Smith AJ. Muskens IS, et al. Among authors: roy r, roy a. Nat Commun. 2021 Feb 5;12(1):821. doi: 10.1038/s41467-021-21064-z. Nat Commun. 2021. PMID: 33547282 Free PMC article.
6,750 results